About this Research Topic
This project is devoted to the publication of high-quality original articles which may contribute to disclosing the mechanisms involved in neurotransmission and neuromodulation at cellular and molecular levels in the nervous system. The interest will be focused on pharmacological studies performed ex vivo or in vivo after the administration of central action drugs in experimental models. They may include the analyses in isolated nervous tissues, slices, subcellular fractions or neuronal and glial cultures. Approaches incorporating experimental models of Alzheimer's and Parkinson's diseases, epilepsy, autism, drug addiction and age-related pathologies will be welcomed. Neurodegenerative diseases are usually associated with mitochondrial bioenergetic impairment, oxidative stress and alterations in calcium homeostasis. Therefore, the interest will also comprise approaches focused on the effect of central action drugs on mitochondrial functionality as well as potential mitochondria-targeted pharmacological drugs for the treatment of neurodegenerative diseases.
Studies regarding the effect of drugs on structural and functional components of the synaptic region, receptor-receptor interactions, and enzyme-receptor interactions at synaptic region will be welcomed. It is expected that contributions regarding the influence of drugs on synaptic plasticity and brain mitochondrial bioenergetics will shed light on the neurotransmission processes.
Approaches at cellular and molecular levels may elucidate the relationship between neuron structure and function. A final goal is to understand the pathogenesis of neurological illness.
Areas of interest to this project include, but are not limited to:
• Effect of drugs on synaptic protein complexes.
• Bidirectional changes in receptor-receptor interactions at synapses by drug administration.
• Changes in enzyme-receptor interactions at synapses by drug administration.
• Effects of drugs on brain mitochondrial bioenergetics and free radical production.
• Alteration of mitochondrial functionality by drug administration concomitant with impairment of neurotransmission processes.
• Drug effects on synaptic adhesivity and remodeling.
Types of manuscripts:
• Original research articles
• Review articles
Keywords: central action drugs, central neurotransmission, enzyme-receptor interactions, receptor-receptor interactions, mitochondrial bioenergetics, mitochondrial functionality, oxidative stress, synaptic adhesivity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.