Research Topic

Parathyroid Atypical Adenomas and Carcinoma: An Update on Clinical Management

About this Research Topic

Primary hyperparathyroidism is a common endocrine disorder mostly due to the presence of an adenoma/single-gland disease. Multiple gland disease or hyperplasia accounts for 10-15% of cases of primary hyperparathyroidism while atypical parathyroid adenoma and parathyroid carcinoma are rare, both responsible for about 1.2-1.3% and 1% or less of primary hyperparathyroidism, respectively. Both atypical parathyroid adenomas and, even more frequently, parathyroid carcinomas are usually presenting with severe hypercalcemia, very high PTH levels, larger volume of parathyroid neoplasia. Prognosis of these tumors mainly depends on early detection and a radical surgical treatment. A strict and continued follow-up is mandatory in order to detect relapse or metastasis . However, over the past few decades there has been no significant trend toward detecting the disease at an earlier stage, with no significant change in patient survival.
The aim of this project will be to present new molecular aspects of these tumors as well as novelty on the genetic profile, the imaging studies, the medical treatment and the surgical techniques.
This Research Topic encourages the contribution of a range of article types, addressing the following aspects of atypical adenomas and parathyroid carcinomas:
· Genetics and molecular aspects;
· Environmental influence;
· Early diagnosis;
· Imaging studies and new technologies;
· Surgical techniques and treatment;
· Medical treatment; and
· Follow-up.


Keywords: primary hyperparathyroidism, parathyroid carcinoma or parathyroid cancer, atypical parathyroid adenoma, parathyroids, parathyroid surgery, endocrine malignancies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Primary hyperparathyroidism is a common endocrine disorder mostly due to the presence of an adenoma/single-gland disease. Multiple gland disease or hyperplasia accounts for 10-15% of cases of primary hyperparathyroidism while atypical parathyroid adenoma and parathyroid carcinoma are rare, both responsible for about 1.2-1.3% and 1% or less of primary hyperparathyroidism, respectively. Both atypical parathyroid adenomas and, even more frequently, parathyroid carcinomas are usually presenting with severe hypercalcemia, very high PTH levels, larger volume of parathyroid neoplasia. Prognosis of these tumors mainly depends on early detection and a radical surgical treatment. A strict and continued follow-up is mandatory in order to detect relapse or metastasis . However, over the past few decades there has been no significant trend toward detecting the disease at an earlier stage, with no significant change in patient survival.
The aim of this project will be to present new molecular aspects of these tumors as well as novelty on the genetic profile, the imaging studies, the medical treatment and the surgical techniques.
This Research Topic encourages the contribution of a range of article types, addressing the following aspects of atypical adenomas and parathyroid carcinomas:
· Genetics and molecular aspects;
· Environmental influence;
· Early diagnosis;
· Imaging studies and new technologies;
· Surgical techniques and treatment;
· Medical treatment; and
· Follow-up.


Keywords: primary hyperparathyroidism, parathyroid carcinoma or parathyroid cancer, atypical parathyroid adenoma, parathyroids, parathyroid surgery, endocrine malignancies


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

24 August 2021 Abstract
22 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

24 August 2021 Abstract
22 December 2021 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..