About this Research Topic
Human body is constantly exposed to Oxidative Stress (OS). Under the effect of radiotherapy or ischemic/reperfusion injuries, OS can result in imbalance between the oxidant and antioxidant in the body, which is a negative effect produced by excess reactive oxygen species (ROS). Since the 1970s, the research of biology and medicine have accumulated a great amount of data, proving that oxidative stress caused by excessive ROS in the body is an important factor involved in the occurrence and development of various human diseases and aging.
Oxidative stress is closely related to many gastrointestinal diseases such as Crohn's disease, ulcerative colitis, and intestinal radiation damage. Oxidative stress induces damages to DNA, mitochondria, cell membrane, which often results in cell apoptosis, necrosis, and other types of programmed cell death. In addition, oxidative injuries in intestine cause destruction to the cellular barrier of intestine, leading to increased permeability and invasion of microbiota. Recently, many attentions have been drawn to this field. However, the following aspects remain to be unaddressed: mechanism in oxidative stress related to gastrointestinal diseases; protective or therapeutic strategies for gastrointestinal diseases; immune dysfunctions in intestine resulted from oxidative stress; novel biomarkers or diagnostic methods for oxidative stress induced gastrointestinal diseases. Hopefully with research performed in the field of oxidative stress, gastroenterology, immunology as well as stem cell biology, will help bring about improvement in diagnosis and treatment for gastrointestinal diseases.
In this Research Topic, we aim to provide an overview of recent progress in Oxidative Stress in the diagnosis and treatment of gastrointestinal disease and seek innovative solutions to resolve existing challenges.
We welcome submissions of Review, Mini-Review and Original Research articles covering, but not limited to, the following topics:
• Intestinal injury from radiotherapy and other oxidative stresses
• Intestine stem cells injury resulted from oxidative stress and free radicals
• Relationship of oxidative response to Inflammation in gastrointestinal system
• Gut microbiome in oxidative stress related disease
Keywords: oxidative stress, gastrointestinal disease, intestinal stem cells, DNA damage repair
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