About this Research Topic
Use of light in Neuro-Oncology can be twofold, for diagnosis and/or for therapeutics. Neurophotonics is the science of photon interaction with neural tissue. Different light-tissue interactions depending on the wavelength of light can provide important information about tissue biological properties down to the cellular level, including highlighting specific molecular signals of tissue, identifying tissue structure, visualizing blood flow through the vessels, determining metabolic profiles and much more. Therefore, the optical bioimaging technologies, such as confocal microscopy, multiphoton tomography, optical coherence tomography, Raman spectroscopy, fluorescence and polarization imaging are the most trending methods to guide surgical procedures and intraoperative “optical” biopsy. Neurosurgical applications of lasers including laser interstitial thermal therapy and photodynamic therapy can provide targeted destruction of brain tumor cells. Moreover the combination of diagnostic and therapeutic applications of light opens the stage for the new developments in biomedical engineering.
The goal of this Research Topic is to assemble a collection of articles that provide a comprehensive review of the state-of-the-art optical imaging and laser technologies used in Neuro-Oncology, to demonstrate their utility, and to present original recent advancements and perspectives in this field.
This Research Topic welcomes neurosurgeons, neuro-oncologists, radiologists, medical interventionists, pathologists, and researchers in optics to publish their original research papers or review papers that target improving intraoperative diagnosis, surgical guidance, extent of tumor resection and outcomes in the field of Neuro-Oncology by using advanced optical imaging and laser technologies, including specific fluorescence labeling, confocal microscopy, multiphoton tomography, optical coherence tomography, polarization imaging, Raman spectroscopy, fluorescence, laser interstitial thermal therapy and photodynamic therapy for either in vivo diagnosis or therapeutic use in Neuro-Oncology. This Research Topic will seek to promote and advance these new optical techniques as a suite of tools for everyone working at the intersection of neurosurgery, biomedical imaging and photonics fields.
Keywords: optical imaging, fluorescence imaging, 5-ALA fluorescence, confocal microscopy, multiphoton tomography, optical coherence tomography, Raman spectroscopy, fluorescence, polarization imaging, laser interstitial thermal therapy, photodynamic therapy, optical biopsy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.