?d T cells are innate-like T cells that serve as an important component in the immune systems of all jawed vertebrates. Under physiological conditions, ?d T cells are identified as an important population in the surveillance of stressed cells, maintenance of tissue homeostasis and intact thermogenesis as well as healthy social behavior. In pathological conditions such as tumor, infection and inflammatory diseases, ?d T cells often contribute to early immune reactions and serve as a vital bridge between the innate immune response and adaptive immune response. The above functions of ?d T cells were carried out via surface innate receptors, secreted cytokines and/or cytotoxic particles. In short, ?d T cells are a functionally heterogeneous population which is necessary for a consummate physiology as well as an intact immune response in pathology. Although significant progresses have been made regarding the functional heterogeneity of ?d T cells, they remain an enigmatic cell population since much less is known about its’ developmental trajectory, subsets programming, antigen recognition, peripheral differentiation as well as communications with other cell types under both physiological and pathological conditions.
The goal of this Research Topic is to provide a forum to advance research on expanding the functional aspects of ?d T cells under both physiological and pathological conditions, to uncover the molecular mechanisms underlying the development, programming, antigen recognition, peripheral differentiation and intercellular communications of ?d T cells as well as to explore innovative ?d T cell immunotherapies in the attempt to achieve a beneficial impact on human diseases or animal models.
We welcome submissions of Original Research, Review and Mini Review on the sub-topics below:
• Novel functions of ?d T cells under either physiological or pathological conditions.
• The developmental trajectory and thymic programming of ?d T cell subsets.
• The molecular mechanisms underlying the tissue-specific distribution of ?d T cells.
• The migration, antigen recognition and activation of ?d T cells under either physiological or pathological conditions.
• The intercellular communication of ?d T cells with ?d T cell subsets, B cells, NK/NKT cells, ILCs, myeloid cells or non-immune cells.
• Prophylactic and/or therapeutic immune strategies based on ?d T cells for human diseases or animal models.
• Innovative methods or antibodies for analysing ?d T cell compartments.
?d T cells are innate-like T cells that serve as an important component in the immune systems of all jawed vertebrates. Under physiological conditions, ?d T cells are identified as an important population in the surveillance of stressed cells, maintenance of tissue homeostasis and intact thermogenesis as well as healthy social behavior. In pathological conditions such as tumor, infection and inflammatory diseases, ?d T cells often contribute to early immune reactions and serve as a vital bridge between the innate immune response and adaptive immune response. The above functions of ?d T cells were carried out via surface innate receptors, secreted cytokines and/or cytotoxic particles. In short, ?d T cells are a functionally heterogeneous population which is necessary for a consummate physiology as well as an intact immune response in pathology. Although significant progresses have been made regarding the functional heterogeneity of ?d T cells, they remain an enigmatic cell population since much less is known about its’ developmental trajectory, subsets programming, antigen recognition, peripheral differentiation as well as communications with other cell types under both physiological and pathological conditions.
The goal of this Research Topic is to provide a forum to advance research on expanding the functional aspects of ?d T cells under both physiological and pathological conditions, to uncover the molecular mechanisms underlying the development, programming, antigen recognition, peripheral differentiation and intercellular communications of ?d T cells as well as to explore innovative ?d T cell immunotherapies in the attempt to achieve a beneficial impact on human diseases or animal models.
We welcome submissions of Original Research, Review and Mini Review on the sub-topics below:
• Novel functions of ?d T cells under either physiological or pathological conditions.
• The developmental trajectory and thymic programming of ?d T cell subsets.
• The molecular mechanisms underlying the tissue-specific distribution of ?d T cells.
• The migration, antigen recognition and activation of ?d T cells under either physiological or pathological conditions.
• The intercellular communication of ?d T cells with ?d T cell subsets, B cells, NK/NKT cells, ILCs, myeloid cells or non-immune cells.
• Prophylactic and/or therapeutic immune strategies based on ?d T cells for human diseases or animal models.
• Innovative methods or antibodies for analysing ?d T cell compartments.
