About this Research Topic
Neurovascular disorders are a group of pathological conditions resulting from neurovascular injury. Neurovascular disorders include cerebral ischemia, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, carotid disease, cerebral small vessel disease, and vascular dementia, among others. Although we have accumulated more understanding of both the genetic links and the basic mechanisms behind the pathophysiology of neurovascular diseases over the years, the exact mechanisms are still unclear. Therefore, there is an urgency to identify important therapeutic targets.
The determination of biomarkers plays an important role in prevention, treatment, and improvement of the prognosis of diseases, and in providing new ideas for further determine causes and mechanisms. Changes in tissue fluids such as blood or cerebrospinal fluid reflect changes in brain parenchymal structure or function and provide key clues in exploring the etiology and mechanism of the disease. Similarly, changes in biomarkers at different stages of disease progression reflect categorization of the disease or variations of factors causing the same disease. Thus, biomarkers bear great importance to accurate diagnosis and precise treatment. For specific neurological diseases, such as vascular dementia, CADASIL, stroke, epilepsy, cerebral small vessel disease, vascular cognitive impairment, spinal cord injury etc, researchers are still looking for biomarkers with high sensitivity and specificity. The discovery of highly efficient biomarkers may partially replace some of the gold standards for invasive diagnosis, enabling a new era of non-invasive or low-invasive precision and individualized treatment.
This Research Topic aims to collect novel articles investigating clinical application of biomarkers for neurovascular disorders, as well as innovation and developments in biomarkers in such disorders. We also encourage submissions probing the mechanisms underlying neurovascular disorders, including but not limited to, Alzheimer’s disease, ischemic stroke, cerebral small vessel disease, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, carotid disease, and vascular dementia.
Both Original Research articles and Review are welcomed.
Topics of interests include but are not limited to:
• Peripheral blood or cerebrospinal fluid biomarkers for neurovascular disorders
• Imaging markers for neurovascular disorders
• Research on pathogenic genes in neurovascular disorders
• Neurovascular disorders and disorders of diet, exercise, and intestinal flora
• Bioinformatics analysis of the prevention, treatment, and prognosis of neurovascular disorders
Keywords: neurovascular, biomarkers, peripheral blood, cerebrospinal fluid, mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.