Research Topic

Purines, Pus, and Pathogens: The Roles of Purinergic Signaling in Inflammation and Immunity

About this Research Topic

Purinergic signaling is a growing area of research investigating the diverse roles of receptors and enzymes that interact with nucleotides and nucleosides such as ATP and adenosine. Purinergic receptors (P1, P2Y, and P2X) and ectonucleotidases (CD39 and CD73) have been widely implicated in health and disease. Here, they contribute to numerous physiological and pathophysiological processes, ranging from control of vascular tone to antiparasitic immune responses. In recent years, there has been increased interest in the roles of purinergic receptors as key mediators of inflammation and immunity following the reception of damage-associated ATP release. We are particularly interested in further uncovering these roles and highlighting the importance of purinergic signaling within pathophysiological processes.



Purinergic receptors are amongst the most abundant receptor type in living organisms and are widely found in the immune system. Here, they are primarily expressed by leukocytes and are involved in a multitude of biological processes, including inflammasome activation, pyroptosis, autophagy, apoptosis, the release of inflammatory mediators, resolution of inflammation, regulation of macrophage polarization, and T cell differentiation. There is now growing evidence that purinergic signaling is involved in the immune response against mycobacteria, viruses, fungi, and parasites. Although our understanding of these roles is still in its infancy. Taken together, purinergic signaling is a complex and intricate system with many roles yet to be uncovered. The purpose of this collection is therefore to compile key advances in the understanding of purinergic signaling within inflammation and immunity and generate a comprehensive resource for all purinergic researchers and immunologists alike.



In this Research Topic, we aim to bring together researchers investigating all aspects of purinergic signaling (P1, P2Y, P2X, CD39, and CD73) and produce a comprehensive overview of the recent developments concerning purinergic signaling within infection and inflammation. We welcome the submission of Review, Original Research, Perspective, Clinical Trial, and Case Report articles covering, but not limited to:



(1) The roles of purinergic signaling in the regulation of innate and adaptive immune responses.

(2) The contribution of purinergic signaling to the pathophysiology of inflammatory disorders.

(3) The deleterious or protective roles of purinergic signaling during pathogenic challenge.

(4) The functional investigation of single nucleotide polymorphisms in purinergic receptors/enzymes associated with altered susceptibility to inflammatory disorders or infection.


Keywords: P1 receptors, P2 receptors, ectonucleotidases, inflammation, immunity, innate and adaptive immune responses, SNPs


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Purinergic signaling is a growing area of research investigating the diverse roles of receptors and enzymes that interact with nucleotides and nucleosides such as ATP and adenosine. Purinergic receptors (P1, P2Y, and P2X) and ectonucleotidases (CD39 and CD73) have been widely implicated in health and disease. Here, they contribute to numerous physiological and pathophysiological processes, ranging from control of vascular tone to antiparasitic immune responses. In recent years, there has been increased interest in the roles of purinergic receptors as key mediators of inflammation and immunity following the reception of damage-associated ATP release. We are particularly interested in further uncovering these roles and highlighting the importance of purinergic signaling within pathophysiological processes.



Purinergic receptors are amongst the most abundant receptor type in living organisms and are widely found in the immune system. Here, they are primarily expressed by leukocytes and are involved in a multitude of biological processes, including inflammasome activation, pyroptosis, autophagy, apoptosis, the release of inflammatory mediators, resolution of inflammation, regulation of macrophage polarization, and T cell differentiation. There is now growing evidence that purinergic signaling is involved in the immune response against mycobacteria, viruses, fungi, and parasites. Although our understanding of these roles is still in its infancy. Taken together, purinergic signaling is a complex and intricate system with many roles yet to be uncovered. The purpose of this collection is therefore to compile key advances in the understanding of purinergic signaling within inflammation and immunity and generate a comprehensive resource for all purinergic researchers and immunologists alike.



In this Research Topic, we aim to bring together researchers investigating all aspects of purinergic signaling (P1, P2Y, P2X, CD39, and CD73) and produce a comprehensive overview of the recent developments concerning purinergic signaling within infection and inflammation. We welcome the submission of Review, Original Research, Perspective, Clinical Trial, and Case Report articles covering, but not limited to:



(1) The roles of purinergic signaling in the regulation of innate and adaptive immune responses.

(2) The contribution of purinergic signaling to the pathophysiology of inflammatory disorders.

(3) The deleterious or protective roles of purinergic signaling during pathogenic challenge.

(4) The functional investigation of single nucleotide polymorphisms in purinergic receptors/enzymes associated with altered susceptibility to inflammatory disorders or infection.


Keywords: P1 receptors, P2 receptors, ectonucleotidases, inflammation, immunity, innate and adaptive immune responses, SNPs


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

30 September 2021 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

30 September 2021 Abstract
31 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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