Research Topic

Mitochondrial and Lysosomal Dysfunction in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Strategies

About this Research Topic

Neurodegenerative diseases are a group of chronic and progressive disorders, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). As the world population ages, more people are suffering from neurodegenerative diseases. Neurodegenerative diseases impose enormous emotional, physical, and financial burdens on patients, their families and society worldwide. Unfortunately, there are no effective treatments that can prevent the development or slow the progression of these diseases.

Mitochondria are known as the powerhouse of the cell, which is responsible for energy production within the cell. Lysosomes are involved in autophagy and act as a waste disposal system by digesting macromolecules. Mitochondrial and lysosomal functions are closely related and critical for maintaining cellular homeostasis. The dysfunction of mitochondria and lysosomes is one of the most essential causes of aging and neurodegenerative diseases. Nevertheless, our understanding of molecular mechanisms of mitochondria, lysosomes, and their interaction in neurodegenerative diseases is limited. Unraveling these mechanisms is crucial for understanding the pathogenesis of neurodegenerative diseases, identifying novel diagnostic and therapeutic targets, developing preventional strategies to reduce disease onset, and discovering therapeutical approaches to slow down the disease progression and to eventually cure these diseases.

This Research Topic focuses on molecular mechanisms of mitochondrial and lysosomal dysfunction in neurodegenerative diseases, especially in PD and AD. Furthermore, we aim to explore therapeutic strategies targeting mitochondria or lysosomes for preventing and treating neurodegenerative diseases.

This Research Topic welcomes all original articles and reviews related, but not limited to, the following sub-topics:
- Mitochondrial and lysosomal metabolism and its roles in PD and AD.
- Mitochondrial and lysosomal quality control in AD and PD
- Molecular mechanisms of mitochondrial and lysosomal crosstalk in neurodegenerative diseases.
- Therapeutic approaches for neurodegenerative diseases that targeting mitochondrial or lysosomal.


Keywords: Mitochondria, lysosome, therapeutic strategies, Parkinson’s disease, Alzheimer’s disease., Molecular Mechanisms


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Neurodegenerative diseases are a group of chronic and progressive disorders, including Parkinson’s disease (PD) and Alzheimer’s disease (AD). As the world population ages, more people are suffering from neurodegenerative diseases. Neurodegenerative diseases impose enormous emotional, physical, and financial burdens on patients, their families and society worldwide. Unfortunately, there are no effective treatments that can prevent the development or slow the progression of these diseases.

Mitochondria are known as the powerhouse of the cell, which is responsible for energy production within the cell. Lysosomes are involved in autophagy and act as a waste disposal system by digesting macromolecules. Mitochondrial and lysosomal functions are closely related and critical for maintaining cellular homeostasis. The dysfunction of mitochondria and lysosomes is one of the most essential causes of aging and neurodegenerative diseases. Nevertheless, our understanding of molecular mechanisms of mitochondria, lysosomes, and their interaction in neurodegenerative diseases is limited. Unraveling these mechanisms is crucial for understanding the pathogenesis of neurodegenerative diseases, identifying novel diagnostic and therapeutic targets, developing preventional strategies to reduce disease onset, and discovering therapeutical approaches to slow down the disease progression and to eventually cure these diseases.

This Research Topic focuses on molecular mechanisms of mitochondrial and lysosomal dysfunction in neurodegenerative diseases, especially in PD and AD. Furthermore, we aim to explore therapeutic strategies targeting mitochondria or lysosomes for preventing and treating neurodegenerative diseases.

This Research Topic welcomes all original articles and reviews related, but not limited to, the following sub-topics:
- Mitochondrial and lysosomal metabolism and its roles in PD and AD.
- Mitochondrial and lysosomal quality control in AD and PD
- Molecular mechanisms of mitochondrial and lysosomal crosstalk in neurodegenerative diseases.
- Therapeutic approaches for neurodegenerative diseases that targeting mitochondrial or lysosomal.


Keywords: Mitochondria, lysosome, therapeutic strategies, Parkinson’s disease, Alzheimer’s disease., Molecular Mechanisms


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

11 September 2021 Abstract
09 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

11 September 2021 Abstract
09 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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