About this Research Topic
Zebrafish (Danio rerio) are robust vertebrate models for studying how cells initiate, maintain, and resolve inflammation, owing to the fact that they are nearly transparent during early development and approximately 70% of genes are conserved with humans. Importantly, they are genetically tractable, with an array of transgenic and mutagenized lines and a full set of molecular tools including CRISPR and morpholino technologies available. The processes underlying cellular inflammation are well conserved among vertebrates, and thus experiments performed using zebrafish models can illuminate our understanding of human inflammation and, in many ways, the overarching processes of development, regeneration, and disease.
The zebrafish can be used to visualize and deconvolute cellular dynamics that initiate, maintain, and ultimately resolve inflammation in vivo. These processes are mediated by an array of genetic factors, including protein-coding genes and non-coding RNAs. In this collection, we aim to gather articles that describe work using zebrafish models intended to define the cellular mechanisms that underlie inflammation in hopes of better understanding processes related to development, regeneration, and disease.
We are interested in collecting manuscripts that describe how immune cells, such as neutrophils and regulatory T cells, regulate inflammation, especially during phases of development, regeneration, or disease. In particular, we would like to collect articles that capture immune cell dynamics during developmental inflammation, classical inflammation, metainflammation and inflammaging, that contribute overall to many pathophysiological conditions in humans. There is an inextricable linkage between disease and inflammation, and the zebrafish, with the assorted disease models that have now been developed, are well suited for understanding the role immune cells play in mediating both protective and detrimental inflammation. An array of development, regeneration, or disease models aimed at understanding the role different immune cells play in mediating inflammation could be considered for this collection, including models of bacterial, fungal, and/or viral infections, tissue injury and regeneration, metabolic diseases, obesity, and aging.
Dr. de Oliveira has a partnership with the company Sparos.
Keywords: zebrafish, inflammation, development, regeneration, disease
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