Research Topic

Chemokines and chemokine receptors in brain homeostasis

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Virtually involved in all pathologies that present an inflammatory component, it is now evident that in the central nervous system, chemokines and chemokines receptor possess pleiotropic properties beyond chemotaxis: constitutive brain expression of chemokines and their receptors on endothelial cells but also ...

Virtually involved in all pathologies that present an inflammatory component, it is now evident that in the central nervous system, chemokines and chemokines receptor possess pleiotropic properties beyond chemotaxis: constitutive brain expression of chemokines and their receptors on endothelial cells but also on neurons and glia suggests a role for such molecules in mediating homeostatic cross-talk between cells of the brain parenchyma. Cross-talk between neurons and glia is determinant to the establishment and maintenance of a brain environment that ensure normal function, and in particular glial cells are active players that respond to enviromental changes and act for the survival, growth, differentiation and repair of the nervous tissue: in this regard brain endogenous chemokines represent key molecules that play a role in brain development, neurogenesis, neurotransmission and neuroprotection.
As important regulators of peripheral immune response, chemokines are molecules of the immune system that play a central role in coordinating communication between the nervous and immune systems in the context of infection and brain injury. Indeed, in pathological processes resulting from infection, brain trauma, ischemia and chronic neurodegenerative diseases chemokines represent important neuroinflammatory mediators that drive leucocytes trafficking into the central nervous system, facilitating an immune response by targeting cells of the innate and adaptive immune system.
The third edition of the international conference “Chemokines and Chemokine Receptors in the Nervous System”, hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to understand the role of chemokines in brain homeostasis.
This Frontiers Reserach Topic arise from this conference, and want to be an opportunity to further discuss and highlight the importance of brain chemokines as key molecules that not only grant the interplay between the immune and nervous system, but in addition drive modulatory function on brain homeostasis orchestrating neuron, microglia, astrocytes communication.
We encourage the submission of original research reports, review articles, commentaries, perspectives or short communications, in the following (but not limited to) topics
- Chemokines in glia-neurons cross-talk
- Chemokines in chemokine receptor in brain development
- Chemokines and neuroprotection
- Chemokines and neuroinflammation


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