The principles of evidence-based medicine have been widely accepted as the golden standard, not only for evaluation of quality of medicines but also for assessing the strength of evidence in healthcare research. Different “levels” of evidence may be possible for strengths of evidence. Prior to the 1962 amendments to the Federal Food, Drug, and Cosmetic Act, many drugs in the market were ineffective and unsafe. Now, controlled trials are widely accepted as the golden standard to ensure safety, efficacy, and quality of drugs. However, controlled trials have their own limitations.
Most recently, real-world data (RWD) and real-world evidence (RWE) are playing an increasing role in healthcare decisions. The evidence may be generated from electronic health records (EHRs), registry data, claims and billing data, patient-generated data, etc. Evidence-based medicine for value in health using different levels of evidence, ranging from controlled trials to RWE, is largely unclear and less discussed. In addition, the role of medication use, access to, and impact on patients' clinical outcomes and economic burden has received less attention.
There are variety of ways to provide evidence-based medicine to inform clinical practice to achieve the best patients’ outcomes possible. The goal of this Research Topic is to provide evidence-based medicine through assessing value of medicines that matter to decision-makers.
We welcome contributions on a range of evidence-based medicine on but not limited to:
• Comparative effectiveness research on clinical effectiveness of medicine use, access, and affordability;
• Pharmacoeconomic research to compare pharmaceutical products and treatment strategies to optimize allocation of health care resources;
• Economic burden of conditions and diseases among older population;
• Meta-analysis to summarize the best evidence-based medicine available in the literature;
• Patient-reported outcomes and quality of life in older patients;
• Health care reform for better access to medicine.
This Research Topic is open to article types including Original Research, Systematic Review, Perspective, and Study Protocol.
Submissions are encouraged from all types of public health systems from across the globe, with a focus on value in health using different “levels” of evidence-based medicine.
The principles of evidence-based medicine have been widely accepted as the golden standard, not only for evaluation of quality of medicines but also for assessing the strength of evidence in healthcare research. Different “levels” of evidence may be possible for strengths of evidence. Prior to the 1962 amendments to the Federal Food, Drug, and Cosmetic Act, many drugs in the market were ineffective and unsafe. Now, controlled trials are widely accepted as the golden standard to ensure safety, efficacy, and quality of drugs. However, controlled trials have their own limitations.
Most recently, real-world data (RWD) and real-world evidence (RWE) are playing an increasing role in healthcare decisions. The evidence may be generated from electronic health records (EHRs), registry data, claims and billing data, patient-generated data, etc. Evidence-based medicine for value in health using different levels of evidence, ranging from controlled trials to RWE, is largely unclear and less discussed. In addition, the role of medication use, access to, and impact on patients' clinical outcomes and economic burden has received less attention.
There are variety of ways to provide evidence-based medicine to inform clinical practice to achieve the best patients’ outcomes possible. The goal of this Research Topic is to provide evidence-based medicine through assessing value of medicines that matter to decision-makers.
We welcome contributions on a range of evidence-based medicine on but not limited to:
• Comparative effectiveness research on clinical effectiveness of medicine use, access, and affordability;
• Pharmacoeconomic research to compare pharmaceutical products and treatment strategies to optimize allocation of health care resources;
• Economic burden of conditions and diseases among older population;
• Meta-analysis to summarize the best evidence-based medicine available in the literature;
• Patient-reported outcomes and quality of life in older patients;
• Health care reform for better access to medicine.
This Research Topic is open to article types including Original Research, Systematic Review, Perspective, and Study Protocol.
Submissions are encouraged from all types of public health systems from across the globe, with a focus on value in health using different “levels” of evidence-based medicine.