About this Research Topic
Respiratory virus infections are a common cause of epidemic outbreaks. Among them, coronaviruses (CoVs) have an important and distinctive place. CoVs are by far the largest group of known positive-sense RNA viruses that have a wide range of natural hosts. In recent decades, coronaviruses have posed a major threat to public health, such as the emergence of SARS-CoV outbreak in 2002, MERS-CoV in 2012 and the current COVID-19 by SAR-CoV-2. Host immune responses to CoVs are essential to control and eliminate virus infections. However, the maladjusted immune responses may result in immune evasion of CoVs. Gaining a thorough understanding of the interaction between CoVs and host immune systems will pave the way for developing broad-spectrum therapeutics and effective vaccines.
The Research Topic will bring together biomedical studies that are more broadly devoted to CoVs interactions (mainly in the respiratory tract) across different viral types, or between different hosts. The aim is to bring together various studies focusing on CoVs infection, host response, virus-host interaction using state-of-the-art approaches and experimental models.
The specific areas of interest include (but are not limited to):
• Evolution of bat-borne CoVs;
• Selection of drugs against CoVs;
• How coronavirus steals our sense of smell and the mechanism behind it;
• Clinical characteristics of people with COVID-19 co-infected with other viruses or bacteria;
• Elucidating receptor recognition, replication, and mechanism of immune evasion of CoVs;
• Development of broad-spectrum vaccines against CoVs.
The following article types are welcome: Original Research, Review, Mini Review, Perspective, General Commentary, and Opinion.
Keywords: Coronavirus, Host-virus interaction, Innate immunity, Host factors, Vaccine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.