About this Research Topic
Extracellular vesicles are released by living cells, in contrast to membrane vesicles released by dying and/or apoptotic cells. Several types of interactions between vesicles and recipient cells have been proposed. These include: A) adhesion of vesicles to the recipient’s cell surface through lipids or ligand–receptor interactions, B) internalization of whole vesicles into endocytic compartments mediated by various receptors and C) fusion of vesicles with the plasma membrane or possibly with internal endosomal membranes. Via these mechanism intracellular contents can be released and signals transduced.
Extracellular vesicles have recently gained interest for therapeutic application in a number fields. These fields can be grouped in four topics:
3- Regenerative therapy
4- Drug delivery
All fields involved in extracellular vesicle research face similar challenges, such as the isolation, identification and quantification of the vesicles, content analysis and functional readout parameters.
In this research topic we encourage submission of original research papers, methods papers and reviews covering various aspects of extracellular vesicle biology up to their therapeutic application.
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