Ion homeostasis plays an important role in the normal physiological function of neuronal cells. Ion imbalance is rapidly restored by activating specific ion channels or ion pumps, resulting in different intracellular signal cascades. The change of ions leads to the transmission of signals between different cells, which constitutes the basis of neuronal transmission. In addition, ion imbalance is the key link to oxidative stress, cell death, aging and major public health diseases. Metal ions are closely related to central nervous system physiology, pathology and toxicity, as well as pharmacological regulation and mechanism. Currently, the research on ion homeostasis and the nervous system has very important scientific value and significance. For example, zinc is an essential element, which is used as a catalyst, structure and regulatory ion in many chronic diseases, including central nervous system diseases. Ferroptosis is new pathogenesis of nervous system diseases, which is closely related to iron imbalance. Therefore, ion changes and ion instability in the occurrence and development of neurological diseases are important research topics for the elucidation of the pathogenic mechanism and early prevention and treatment of neurological diseases.
In this Research Topic, we would like to study the regulatory effect and mechanism of metal ions on the central nervous system. We hope to lead discussions on ion homeostasis and imbalance in the control of central nervous system physiological mechanism, the role of metal ion related neurotoxicity in the pathogenesis of neurological disorders (AD, PD, cerebrovascular disease, epilepsy, etc.), and the role of ion chelators or supplements in the intervention and treatment of central nervous system diseases. These studies will help to clarify the role of metal ions (calcium, magnesium, zinc, iron, copper, manganese, cadmium etc.), and to enrich the understanding of molecular mechanisms in the field of ion regulation and promote the further transformation and clinical application of research results.
This Research Topic will focus on the regulatory role and mechanism of metal ions on the physiology, pathology, pharmacology and toxicology of the central nervous system, to deepen the understanding of ion imbalance on the pathogenic mechanism of related diseases, and to open up a new interpretation perspective. Animal models and cell cultures that are often used to explore the mechanism of ion homeostasis and the nervous system are welcome. Both Original Research articles and reviews are welcomed.
This Research Topic focuses on the following research topics:
- Study on the physiological regulatory mechanism of metal ions on the central nervous system, including how they affect the survival and death of neuronal cells
- The relationship between metal ions and the pathogenesis of central nervous system diseases (AD, PD, cerebrovascular disease, epilepsy, etc.)
- The toxic effect and mechanism of metal ions on the central nervous system
- Effects of metal ion chelators or supplements on the intervention and treatment of central nervous system diseases
Ion homeostasis plays an important role in the normal physiological function of neuronal cells. Ion imbalance is rapidly restored by activating specific ion channels or ion pumps, resulting in different intracellular signal cascades. The change of ions leads to the transmission of signals between different cells, which constitutes the basis of neuronal transmission. In addition, ion imbalance is the key link to oxidative stress, cell death, aging and major public health diseases. Metal ions are closely related to central nervous system physiology, pathology and toxicity, as well as pharmacological regulation and mechanism. Currently, the research on ion homeostasis and the nervous system has very important scientific value and significance. For example, zinc is an essential element, which is used as a catalyst, structure and regulatory ion in many chronic diseases, including central nervous system diseases. Ferroptosis is new pathogenesis of nervous system diseases, which is closely related to iron imbalance. Therefore, ion changes and ion instability in the occurrence and development of neurological diseases are important research topics for the elucidation of the pathogenic mechanism and early prevention and treatment of neurological diseases.
In this Research Topic, we would like to study the regulatory effect and mechanism of metal ions on the central nervous system. We hope to lead discussions on ion homeostasis and imbalance in the control of central nervous system physiological mechanism, the role of metal ion related neurotoxicity in the pathogenesis of neurological disorders (AD, PD, cerebrovascular disease, epilepsy, etc.), and the role of ion chelators or supplements in the intervention and treatment of central nervous system diseases. These studies will help to clarify the role of metal ions (calcium, magnesium, zinc, iron, copper, manganese, cadmium etc.), and to enrich the understanding of molecular mechanisms in the field of ion regulation and promote the further transformation and clinical application of research results.
This Research Topic will focus on the regulatory role and mechanism of metal ions on the physiology, pathology, pharmacology and toxicology of the central nervous system, to deepen the understanding of ion imbalance on the pathogenic mechanism of related diseases, and to open up a new interpretation perspective. Animal models and cell cultures that are often used to explore the mechanism of ion homeostasis and the nervous system are welcome. Both Original Research articles and reviews are welcomed.
This Research Topic focuses on the following research topics:
- Study on the physiological regulatory mechanism of metal ions on the central nervous system, including how they affect the survival and death of neuronal cells
- The relationship between metal ions and the pathogenesis of central nervous system diseases (AD, PD, cerebrovascular disease, epilepsy, etc.)
- The toxic effect and mechanism of metal ions on the central nervous system
- Effects of metal ion chelators or supplements on the intervention and treatment of central nervous system diseases