Diabetes is a metabolic disease characterized by high blood glucose, affecting 463 million people worldwide. Prevalence has been rising more rapidly. Untreated high blood glucose can damage nerves, eyes, kidneys, muscles, and other organs. Specifically, the muscles play a notable role in the regulation of blood glucose. Thus, muscle damage induced by high blood glucose contributes to the progression of additional diabetic complications, leading to impaired quality of life and high mortality in the patients. Despite substantial efforts to develop medical interventions, understanding the mechanistic basis of diabetic myopathy is still required to develop therapeutic approaches for patients with diabetes. Regular exercise has been shown to improve insulin sensitivity and enhance glucose uptake as a powerful non-pharmacological intervention for patients with diabetes. Exercise facilitates beneficial effects in muscles, including enhanced mitochondrial function, improved antioxidant capacity, attenuated inflammation, etc. in the progression of diabetic myopathy. The goal of this research topic is to identify novel mechanisms of how exercise prevent and/ or improve muscles from diabetic myopathy.
We welcome the submission of original research article, and review article on the following scope, but not limited to topic below:
- How exercise improves mitochondrial function in muscles from diabetic myopathy.
- How exercise attenuates oxidative stress and enhances antioxidant capacity in muscle against diabetic myopathy.
- How exercise regulates muscle stem cells in skeletal muscle of diabetic myopathy.
Diabetes is a metabolic disease characterized by high blood glucose, affecting 463 million people worldwide. Prevalence has been rising more rapidly. Untreated high blood glucose can damage nerves, eyes, kidneys, muscles, and other organs. Specifically, the muscles play a notable role in the regulation of blood glucose. Thus, muscle damage induced by high blood glucose contributes to the progression of additional diabetic complications, leading to impaired quality of life and high mortality in the patients. Despite substantial efforts to develop medical interventions, understanding the mechanistic basis of diabetic myopathy is still required to develop therapeutic approaches for patients with diabetes. Regular exercise has been shown to improve insulin sensitivity and enhance glucose uptake as a powerful non-pharmacological intervention for patients with diabetes. Exercise facilitates beneficial effects in muscles, including enhanced mitochondrial function, improved antioxidant capacity, attenuated inflammation, etc. in the progression of diabetic myopathy. The goal of this research topic is to identify novel mechanisms of how exercise prevent and/ or improve muscles from diabetic myopathy.
We welcome the submission of original research article, and review article on the following scope, but not limited to topic below:
- How exercise improves mitochondrial function in muscles from diabetic myopathy.
- How exercise attenuates oxidative stress and enhances antioxidant capacity in muscle against diabetic myopathy.
- How exercise regulates muscle stem cells in skeletal muscle of diabetic myopathy.
