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Blast-induced Neurotrauma Models and Their Requirements

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The injurious environment generated by explosion is very complex where multiple blast effects often interact with the body and brain either simultaneously or consecutively. Thus, the resulting blast-induced neurotrauma is a unique clinical entity induced by systemic, local, and cerebral responses. Current ...

The injurious environment generated by explosion is very complex where multiple blast effects often interact with the body and brain either simultaneously or consecutively. Thus, the resulting blast-induced neurotrauma is a unique clinical entity induced by systemic, local, and cerebral responses. Current experimental models of blast injuries used to study blast-induced neurotrauma vary widely, which makes the comparison of the experimental results extremely challenging and could lead to misleading results. The goals of this special forum are to: 1) address the main physical properties of blast and identify its main components a clinically relevant experimental model should reproduce; 2) describe the main functional neurological impairments observed in individuals exposed to blast, which a reliable experimental model should be able to reproduce; 3) provide an overview of the existing animal models and discuss their pros and cons; and 4) incorporate the information provided by presented articles in a consensus document providing a guideline for basic requirements for a clinically relevant experimental model of blast-induced neurotrauma.


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