Cardiovascular disease is still the main reason for disease-related death worldwide, causing substantial economic and social burdens. Massive evidence has demonstrated that dysregulation of metabolism is a common feature in various cardiovascular diseases. Additionally, dysregulation of metabolic substrates may contribute to multi-organ disorders. For instance, lipid metabolic dysfunction associated with inflammation and oxidative stress has been recognized as the primary driver of the pathological changes of myocardial ischemia. Meanwhile, oxygen deficiency and oxidative stress can damage myocardial mitochondria and inhibit the activity of tricarboxylic acid cycle enzymes, leading to energy and amino acid metabolism disorders. Therefore, restoring normal metabolic processes represents a promising therapeutic strategy for cardiovascular disease.
Flavonoids are the most common group of dietary polyphenolic compounds that are present in plants or food. They have a variety of biological activities, including anti-inflammatory and antioxidant activities, as well as significant therapeutic effects on cardiovascular diseases. However, a better understanding of flavonoids and their impact on metabolic regulatory processes and gene regulation of cellular metabolism in cardiovascular diseases is needed.
This Research Topic offers the opportunity to emphasize the importance of flavonoids in plants or food on cardiovascular metabolism. Authors are welcome to submit Original Research and Review articles that contain novel data regarding the possibility of flavonoids interventions and clarifications of underline metabolic mechanisms in cardiovascular diseases.
Specifically, we would like to invite submissions with the following themes:
1) Role of flavonoids on the reduction of risk factors of cardiovascular metabolism;
2) Metabolic pathways affected by flavonoids in cardiovascular diseases;
3) Effects of flavonoids on cardiometabolic diseases;
4) Gut-heart axis in the protective effects of flavonoids on cardiovascular metabolism;
5) Regulation of lipid and/or amino acid metabolism by flavonoids in cardiovascular diseases.
Cardiovascular disease is still the main reason for disease-related death worldwide, causing substantial economic and social burdens. Massive evidence has demonstrated that dysregulation of metabolism is a common feature in various cardiovascular diseases. Additionally, dysregulation of metabolic substrates may contribute to multi-organ disorders. For instance, lipid metabolic dysfunction associated with inflammation and oxidative stress has been recognized as the primary driver of the pathological changes of myocardial ischemia. Meanwhile, oxygen deficiency and oxidative stress can damage myocardial mitochondria and inhibit the activity of tricarboxylic acid cycle enzymes, leading to energy and amino acid metabolism disorders. Therefore, restoring normal metabolic processes represents a promising therapeutic strategy for cardiovascular disease.
Flavonoids are the most common group of dietary polyphenolic compounds that are present in plants or food. They have a variety of biological activities, including anti-inflammatory and antioxidant activities, as well as significant therapeutic effects on cardiovascular diseases. However, a better understanding of flavonoids and their impact on metabolic regulatory processes and gene regulation of cellular metabolism in cardiovascular diseases is needed.
This Research Topic offers the opportunity to emphasize the importance of flavonoids in plants or food on cardiovascular metabolism. Authors are welcome to submit Original Research and Review articles that contain novel data regarding the possibility of flavonoids interventions and clarifications of underline metabolic mechanisms in cardiovascular diseases.
Specifically, we would like to invite submissions with the following themes:
1) Role of flavonoids on the reduction of risk factors of cardiovascular metabolism;
2) Metabolic pathways affected by flavonoids in cardiovascular diseases;
3) Effects of flavonoids on cardiometabolic diseases;
4) Gut-heart axis in the protective effects of flavonoids on cardiovascular metabolism;
5) Regulation of lipid and/or amino acid metabolism by flavonoids in cardiovascular diseases.
