Cancers affecting the peritoneal cavity have a unique microenvironment, thus presenting novel targets for treatment. The peritoneal microenvironment differs from solid organ sites of cancer based on its blood supply, affecting a range of issues including metastatic processes, drug penetrance, oxygenation, metabolism, and immunity.
The goal of this Research Topic is to present research that identifies new targeted approaches to treating cancer in the peritoneal cavity. This may include newly discovered drug targets, re-purposing of existing drugs, or new methods of drug delivery.
Research may include new targets identified that pertain to tumor hypoxia and related metabolic changes, tumor blood flow, drug delivery and drug metabolism. Research studying the cancer cells themselves, the microenvironment, or the immune milieu are encouraged. Potential treatments can include chemotherapy, targeted therapy, or immunotherapy. Authors are invited to submit original research or insightful literature reviews.
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Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Cancers affecting the peritoneal cavity have a unique microenvironment, thus presenting novel targets for treatment. The peritoneal microenvironment differs from solid organ sites of cancer based on its blood supply, affecting a range of issues including metastatic processes, drug penetrance, oxygenation, metabolism, and immunity.
The goal of this Research Topic is to present research that identifies new targeted approaches to treating cancer in the peritoneal cavity. This may include newly discovered drug targets, re-purposing of existing drugs, or new methods of drug delivery.
Research may include new targets identified that pertain to tumor hypoxia and related metabolic changes, tumor blood flow, drug delivery and drug metabolism. Research studying the cancer cells themselves, the microenvironment, or the immune milieu are encouraged. Potential treatments can include chemotherapy, targeted therapy, or immunotherapy. Authors are invited to submit original research or insightful literature reviews.
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Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
