Age-related neurodegenerative diseases are a type of progressive disorders that include Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia (FTD) and others. As the population ages, the number of people affected by these age-related diseases is increasing. Posttranslational modifications (PTMs) are crucial for protein function. These PTMs include but are not limited to, phosphorylation, ubiquitination, methylation, acetylation, SUMOylation, and nitrosylation. PTMs normally regulate the activity, stability, interactions, and intracellular distribution of proteins, which enable cells to adequately respond to stress. Damaged and misfolded proteins accumulate with age. The pathogenesis of age-related neurodegenerative diseases is closely related to the malfunction of various proteins. Dysregulation of PTMs is associated with protein mislocalization and malfunction, and thus are key players in the pathogenesis of age-related neurodegenerative diseases.
Dysregulated PTMs, which may be caused by many reasons, have been linked to the onset and progression of many of these age-related neurodegenerative diseases. Therefore, it is crucial to gain a deep understanding of the molecular regulatory mechanisms of posttranslational modifications, the consequences of the dysregulation of posttranslational modifications at molecular, cellular and organismal levels, and the extent to which these modifications are reversible. The advancement of modern molecular biology, biochemistry, neurobiology, genetic and epigenetic has provided a great opportunity for us to investigate the role of PTMs in age-related neurodegenerative diseases. These researches will also help in the development of new preventative and therapeutic approaches for age-related neurodegenerative diseases.
This Research Topic welcomes all original articles, reviews and reports related, but not limited to, the following sub-topics:
- The genetic and environmental factors that regulate PTMs in age-related neurodegenerative diseases
- The key mechanism underlying the activation and regulation of PTMs in age-related neurodegenerative diseases
- Dysregulated PTMs as the base of protein misfolding in age-related neurodegenerative diseases
- Targeting PTMs as a therapeutic strategy for age-related neurodegenerative diseases
- The emerging role of transnitrosylation in age-related neurodegenerative diseases
- The involvement of abnormal protein posttranslational modification networks in the pathogenesis of age-related neurodegenerative diseases
Age-related neurodegenerative diseases are a type of progressive disorders that include Alzheimer’s disease, Parkinson’s disease, frontotemporal dementia (FTD) and others. As the population ages, the number of people affected by these age-related diseases is increasing. Posttranslational modifications (PTMs) are crucial for protein function. These PTMs include but are not limited to, phosphorylation, ubiquitination, methylation, acetylation, SUMOylation, and nitrosylation. PTMs normally regulate the activity, stability, interactions, and intracellular distribution of proteins, which enable cells to adequately respond to stress. Damaged and misfolded proteins accumulate with age. The pathogenesis of age-related neurodegenerative diseases is closely related to the malfunction of various proteins. Dysregulation of PTMs is associated with protein mislocalization and malfunction, and thus are key players in the pathogenesis of age-related neurodegenerative diseases.
Dysregulated PTMs, which may be caused by many reasons, have been linked to the onset and progression of many of these age-related neurodegenerative diseases. Therefore, it is crucial to gain a deep understanding of the molecular regulatory mechanisms of posttranslational modifications, the consequences of the dysregulation of posttranslational modifications at molecular, cellular and organismal levels, and the extent to which these modifications are reversible. The advancement of modern molecular biology, biochemistry, neurobiology, genetic and epigenetic has provided a great opportunity for us to investigate the role of PTMs in age-related neurodegenerative diseases. These researches will also help in the development of new preventative and therapeutic approaches for age-related neurodegenerative diseases.
This Research Topic welcomes all original articles, reviews and reports related, but not limited to, the following sub-topics:
- The genetic and environmental factors that regulate PTMs in age-related neurodegenerative diseases
- The key mechanism underlying the activation and regulation of PTMs in age-related neurodegenerative diseases
- Dysregulated PTMs as the base of protein misfolding in age-related neurodegenerative diseases
- Targeting PTMs as a therapeutic strategy for age-related neurodegenerative diseases
- The emerging role of transnitrosylation in age-related neurodegenerative diseases
- The involvement of abnormal protein posttranslational modification networks in the pathogenesis of age-related neurodegenerative diseases