About this Research Topic
Variants of interest often emerge as variants under investigation in one or more countries, as seen with the Omicron (initially denoted as Nu in South Africa). They become variants of concern when there is evidence of increased transmissibility, greater case severity, loss of neutralization by antibodies, and reduced effectiveness of countermeasures. Some SARS-CoV-2 variants can infect new hosts (for instance, the Alpha, Beta and Gamma variants of concern can infect wild type mice which is a species that cannot be vaccinated or controlled easily), and/or reduce the effectiveness of vaccines and therapies (especially Beta and Delta); diagnostic tests have also been reported to be affected. Currently, we do not yet have any ‘variant of high consequence’ with confirmed attributes such as widespread diagnostic test failures, significant reduction in the effectiveness of vaccines and/or therapies, with greater disease severity and deaths. It remains to be seen if Omicron would be the first to be declared by the WHO as a variant of high consequence; more variants of concern are also likely to be declared by the WHO over the next couple of years. Therefore, our ability to control and conquer this pandemic over the long run is dependent on predicting and keeping up with the evolution of this virus, its new hosts, as well as understanding and mitigating its impact on diagnostics, vaccines and therapies.
A clear understanding of the evolution of SARS-CoV-2 is paramount for combatting COVID-19 as the pandemic becomes endemic. Therefore, we are editing a special collection of peer-reviewed papers of topical importance on “Evolution of SARS-CoV-2: impact of variants on new hosts, COVID-19 diagnostics, vaccines and therapies”. Recent advances in artificial intelligence, bioinformatics, biomolecular modelling, diagnostics, prognostics, systems biology, therapeutics, vaccinology and virology – to name a few – will be key to our resilience and response so we welcome submissions from multi-disciplinary authors.
Keywords: COVID-19; Countermeasures; Diagnostics; SARS-CoV-2; Variants
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.