Non-alcoholic fatty liver disease (NAFLD) has become a serious health problem worldwide because of its high prevalence. However, there are currently no specific and effective pharmacological therapies due to an incomplete understanding of its molecular mechanisms. Recent studies have demonstrated that secreted factors produced from the liver, adipose tissue and skeletal muscle, such as FGF21, Adiponectin and Nrg4, play crucial roles in the regulation of metabolic processes, including hepatic lipid homeostasis. These secreted factors are called ‘Hepatokines’, ‘Adipokines’ and ‘Myokines’. Under the physiological state, they can modulate hepatic lipogenesis, fatty acid oxidation and lipid transport in the liver. On the other hand, dysregulation of these factors would contribute to abnormal lipid metabolism, resulting in hepatic steatosis and/or steatohepatitis. Therefore, further investigation into the roles and mechanisms of ‘Hepatokines’, ‘Adipokines’ and ‘Myokines’, and identification of novel ‘Organokines’ may help to explore the molecular mechanisms of NAFLD and seek potential therapeutic targets for its treatment.
This Research Topic aims to:
1) provide insight into the roles and mechanisms of secreted factors in the regulation of hepatic lipid metabolism
2) identify novel hepatokines, adipokines and myokines that may regulate the development and progression of NAFLD and related chronic metabolic liver diseases.
3) build up the relationship between hepatokines, adipokines, myokines and NAFLD in human populations.
This Research Topic welcomes Original Research and Review Articles focusing on, but not restricted to the factors in the regulation of NAFLD and related chronic liver diseases, including 1) Hepatokines, 2) Adipokines, 3) Myokines, as well as Human studies on the relationship between hepatokines, adipokines and myokines with NAFLD.
Non-alcoholic fatty liver disease (NAFLD) has become a serious health problem worldwide because of its high prevalence. However, there are currently no specific and effective pharmacological therapies due to an incomplete understanding of its molecular mechanisms. Recent studies have demonstrated that secreted factors produced from the liver, adipose tissue and skeletal muscle, such as FGF21, Adiponectin and Nrg4, play crucial roles in the regulation of metabolic processes, including hepatic lipid homeostasis. These secreted factors are called ‘Hepatokines’, ‘Adipokines’ and ‘Myokines’. Under the physiological state, they can modulate hepatic lipogenesis, fatty acid oxidation and lipid transport in the liver. On the other hand, dysregulation of these factors would contribute to abnormal lipid metabolism, resulting in hepatic steatosis and/or steatohepatitis. Therefore, further investigation into the roles and mechanisms of ‘Hepatokines’, ‘Adipokines’ and ‘Myokines’, and identification of novel ‘Organokines’ may help to explore the molecular mechanisms of NAFLD and seek potential therapeutic targets for its treatment.
This Research Topic aims to:
1) provide insight into the roles and mechanisms of secreted factors in the regulation of hepatic lipid metabolism
2) identify novel hepatokines, adipokines and myokines that may regulate the development and progression of NAFLD and related chronic metabolic liver diseases.
3) build up the relationship between hepatokines, adipokines, myokines and NAFLD in human populations.
This Research Topic welcomes Original Research and Review Articles focusing on, but not restricted to the factors in the regulation of NAFLD and related chronic liver diseases, including 1) Hepatokines, 2) Adipokines, 3) Myokines, as well as Human studies on the relationship between hepatokines, adipokines and myokines with NAFLD.
