About this Research Topic
The overall aim of this special issue is to build a better understanding of the contribution and significance of THs impact on cancer cells and on the associated antitumor immune response. The issue will focus on studies showing the influence of thyroid hormones on genetic, molecular, or cellular mechanisms that are involved in tumorigenesis, cancer metabolism, tumor proliferation/survival, and cancer progression. The effects of THs on the composition of the tumor microenvironment and the antitumor immune responses will also be discussed. The knowledge of the mechanisms of thyroid hormone actions in cancer could lead to the identification of new therapeutic targets or to the use of the modulation of the thyroid status to improve treatment outcomes in patients.
The scope of this special issue will include research on THs actions on:
(i) cancer cells themselves,
(ii) tumor microenvironment,
(iii) antitumor immune response.
Studies may include preclinical research on the effects of THs in different cancer models, both in vitro and in vivo. We also encourage clinical studies examining various aspects of the association of patients' thyroid status and cancer, including cancer risk, behavior, and outcome.
Authors are invited to submit original research, review, or mini-review articles that cover recent and current knowledge on the thyroid hormone effects in different types of cancer. Reviews or mini-reviews should focus on a specific cancer model including breast, renal, prostate, lung, gynecological, thyroid, gastrointestinal, skin, central nervous, or hematological cancers.
Keywords: INTEGRIN ALPHA V BETA 3, CANCER PROGRESSION, ANTITUMOR IMMUNITY, DEIODINASES, Thyroid Hormones, Thyroid Hormone Receptor
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.