In recent years, dietary bioactive polysaccharides have attracted more attention due to their non-harmful and non-toxic properties. Abundant studies have identified valuable biological activities of dietary bioactive polysaccharides, especially immunomodulating activity. Previous studies have shown that the mechanisms involved in immunomodulating effects are due to the modulation of innate immunity and macrophage function. However, the underlying cellular signaling and molecular mechanisms of their immunomodulating activity are not clear. In this respect, this special issue will collect and summarize the immunomodulatory effects of dietary bioactive polysaccharides (such as inulin, dietary gum, fucoidan, glucan, glucomannan, heteropolysaccharides, etc.) from different natural sources (such as fruits and vegetables, cereal grains, edible mushrooms, seafoods, medicinal plants) in immune cells, animal study and clinical study as well.
This Research Topic aims to fill the gap between the knowledge on significant therapeutic immunomodulating activities of dietary polysaccharides and their underlying cellular signaling and molecular mechanisms. It also aims to accumulate new knowledge and methods for the discovery and development of novel therapeutic agents and adjuvants that exhibit beneficial immunomodulatory properties.
The specific areas of interest include (but are not limited to):
• The intrinsic immunomodulating activity of dietary bioactive polysaccharides from natural sources, such as mushrooms, plants, brown seeds.
• In vitro studies (RAW 264.7 cells, human plasmacytoid dendritic cells and mouse spleen lymphocytes), animal studies and human studies on the immunomodulating activity of dietary bioactive polysaccharides.
• The exact interleukins (ILs), tumor necrosis factor-alpha (TNF)-α, interferon-gamma (INF)-γ, prostaglandinE2 (PGE2), NF-kappaB, PI3K/Akt and MAPK and Toll-like receptor (TLR4) signaling pathways of immunomodulating activity.
• The activation of macrophage immune responses by dietary bioactive polysaccharides (including increasing reactive oxygen species (ROS) production and enhancing the secretion of cytokines and chemokines).
• Gut microbiota-related immune modulation study is excluded as such kinds of studies have been covered in other Research Topics.
In recent years, dietary bioactive polysaccharides have attracted more attention due to their non-harmful and non-toxic properties. Abundant studies have identified valuable biological activities of dietary bioactive polysaccharides, especially immunomodulating activity. Previous studies have shown that the mechanisms involved in immunomodulating effects are due to the modulation of innate immunity and macrophage function. However, the underlying cellular signaling and molecular mechanisms of their immunomodulating activity are not clear. In this respect, this special issue will collect and summarize the immunomodulatory effects of dietary bioactive polysaccharides (such as inulin, dietary gum, fucoidan, glucan, glucomannan, heteropolysaccharides, etc.) from different natural sources (such as fruits and vegetables, cereal grains, edible mushrooms, seafoods, medicinal plants) in immune cells, animal study and clinical study as well.
This Research Topic aims to fill the gap between the knowledge on significant therapeutic immunomodulating activities of dietary polysaccharides and their underlying cellular signaling and molecular mechanisms. It also aims to accumulate new knowledge and methods for the discovery and development of novel therapeutic agents and adjuvants that exhibit beneficial immunomodulatory properties.
The specific areas of interest include (but are not limited to):
• The intrinsic immunomodulating activity of dietary bioactive polysaccharides from natural sources, such as mushrooms, plants, brown seeds.
• In vitro studies (RAW 264.7 cells, human plasmacytoid dendritic cells and mouse spleen lymphocytes), animal studies and human studies on the immunomodulating activity of dietary bioactive polysaccharides.
• The exact interleukins (ILs), tumor necrosis factor-alpha (TNF)-α, interferon-gamma (INF)-γ, prostaglandinE2 (PGE2), NF-kappaB, PI3K/Akt and MAPK and Toll-like receptor (TLR4) signaling pathways of immunomodulating activity.
• The activation of macrophage immune responses by dietary bioactive polysaccharides (including increasing reactive oxygen species (ROS) production and enhancing the secretion of cytokines and chemokines).
• Gut microbiota-related immune modulation study is excluded as such kinds of studies have been covered in other Research Topics.