About this Research Topic
Ovarian cancer requires the identification of potential therapies and treatments for ovarian cancer to improve the survival rate and prognosis of the disease. However, studies have demonstrated that therapies and treatments can be influenced by molecular mechanisms that need to be further studied. Studies have found that an active therapeutic target for combination treatment was found to be the DNA damage response pathway, such as Poly (ADP-ribose) polymerase (PARP). PARP inhibitors have been found to cause DNA damage via the catalytic inhibition of the PARP enzyme resulting in strengthening the killing of tumor cells. Further studies have explored the role of Acyl-CoA medium-chain synthetase-3 (ACSM3), which is a sub-unit of CoA ligases known to influence the progression of many diseases. ACSM3 has been found to be differentially expressed in multiple cancers which influence poor prognosis and low survival rates. ACSM3 has been found to be down-regulated in ovarian cancer which reflects poor survival as it influences cell migration, proliferation and invasion of ovarian cancer cells. Studies have also demonstrated that ITG β1 (Integrin β1) expressed an upregulation in ovarian cancer tissues and the overexpression was associated with poor prognosis in addition to a more advanced stage of the disease.
Further research is required to identify and establish potential molecular factors which influence the treatment and therapies of ovarian cancer. This Research Topic aims to generate a discussion around the research regarding molecular influences in ovarian cancer. We welcome Original Research Articles, Review Articles, Systematic Reviews and Mini Reviews.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: ovarian cancer, therapy, treatment, molecular, metastatic, epithelial mesenchymal transition
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