Cell signaling, including intracellular signaling, extracellular signaling and even microbial signaling, is an effective and efficient form of communication, which help us to respond and adapt to the internal and external environments. Properly functioning cell-signaling pathways are essential to maintain homeostasis of cell and the health status of living systems. Specifically, dysfunction of immune cell signaling has frequently reported to be pathological hallmarks for various human disease (e.g. cancer, sepsis, autoimmune diseases and Alzheimer's disease) and immunotherapy plays very important role in the treatment of various diseases. Of note, the intercellular signaling and cellular communications are critical for the orchestrating of unified and synergistic response to environmental cues during the development and diseases. Most recently, researchers have revealed that the interaction and crosstalk between microbiota and the host is essential for sustaining the host's physiology and homeostasis, and disruption of this “coexistence” has been associated with various diseases, such as neurodegenerative diseases, cardiovascular diseases, metabolic diseases and even cancer. Therefore, a depth-study of these cell signals can facilitate our understanding of cell development and can also offer us clues to the diagnosis and therapy of diseases.
With the development of sequence technologies and the application of effective bioinformatic tools, various cell signalings can be measured and decoupled. However, many questions remain to be answered. On one hand, deeper explorations in these signaling pathways is essential to expand our knowledge about the association between various signaling pathways and human behavior and diseases. On the other hand, as our biosystem is sophisticated, integrative analysis of different signaling pathways is necessary which can provide us more comprehensive map of cell development and the disease occurrence and progression.
With the development of sequence technologies and the application of effective bioinformatic tools, various cell signalings can be measured and decoupled. However, many questions remain to be answered. On one hand, deeper explorations in these signaling pathways is essential to expand our knowledge about the association between various signaling pathways and human behavior and diseases. On the other hand, as our biosystem is sophisticated, integrative analysis of different signaling pathways is necessary which can provide us more comprehensive map of cell development and the disease occurrence and progression.
This Research Topic aims to put together novel articles providing new insights into the roles of cell signaling in development and disease occurrence and progression. We welcome the submission of Original Research Articles, Reviews, and Mini-reviews, including but not limited to the following topics:
l Revealing the status alteration of cell signaling in embryogenesis, metamorphosis, and aging.
l Identification of novel biomarkers that closely associated with disease occurrence and progression through integrating multiple signaling pathways.
l Role of microbial signaling in disease occurrence, progression, and therapy.
l Crosstalk among intracellular signaling, extracellular signaling and microbial signaling.
Cell signaling, including intracellular signaling, extracellular signaling and even microbial signaling, is an effective and efficient form of communication, which help us to respond and adapt to the internal and external environments. Properly functioning cell-signaling pathways are essential to maintain homeostasis of cell and the health status of living systems. Specifically, dysfunction of immune cell signaling has frequently reported to be pathological hallmarks for various human disease (e.g. cancer, sepsis, autoimmune diseases and Alzheimer's disease) and immunotherapy plays very important role in the treatment of various diseases. Of note, the intercellular signaling and cellular communications are critical for the orchestrating of unified and synergistic response to environmental cues during the development and diseases. Most recently, researchers have revealed that the interaction and crosstalk between microbiota and the host is essential for sustaining the host's physiology and homeostasis, and disruption of this “coexistence” has been associated with various diseases, such as neurodegenerative diseases, cardiovascular diseases, metabolic diseases and even cancer. Therefore, a depth-study of these cell signals can facilitate our understanding of cell development and can also offer us clues to the diagnosis and therapy of diseases.
With the development of sequence technologies and the application of effective bioinformatic tools, various cell signalings can be measured and decoupled. However, many questions remain to be answered. On one hand, deeper explorations in these signaling pathways is essential to expand our knowledge about the association between various signaling pathways and human behavior and diseases. On the other hand, as our biosystem is sophisticated, integrative analysis of different signaling pathways is necessary which can provide us more comprehensive map of cell development and the disease occurrence and progression.
With the development of sequence technologies and the application of effective bioinformatic tools, various cell signalings can be measured and decoupled. However, many questions remain to be answered. On one hand, deeper explorations in these signaling pathways is essential to expand our knowledge about the association between various signaling pathways and human behavior and diseases. On the other hand, as our biosystem is sophisticated, integrative analysis of different signaling pathways is necessary which can provide us more comprehensive map of cell development and the disease occurrence and progression.
This Research Topic aims to put together novel articles providing new insights into the roles of cell signaling in development and disease occurrence and progression. We welcome the submission of Original Research Articles, Reviews, and Mini-reviews, including but not limited to the following topics:
l Revealing the status alteration of cell signaling in embryogenesis, metamorphosis, and aging.
l Identification of novel biomarkers that closely associated with disease occurrence and progression through integrating multiple signaling pathways.
l Role of microbial signaling in disease occurrence, progression, and therapy.
l Crosstalk among intracellular signaling, extracellular signaling and microbial signaling.