Research Topic

Cerebral Small Vessel Disease: From the Pathogenesis to Therapeutic Interventions

About this Research Topic

Cerebral small vessel disease (CSVD) is caused by several different pathophysiologic mechanisms that mostly affect the small arteries, arterioles, venules, and capillaries of the brain. It is a common cause of stroke and dementia in elderly people, accounting for up to nearly half of all dementias and 25-30% of all strokes worldwide.

The pathogenesis of CSVD is still unclear. Although many risk factors of CSVD have been identified, including hypertension, diabetic mellitus, dyslipidemia, endothelial dysfunction, inflammation, oxidative stress, cerebral amyloid angiopathy, and several genetic disorders. However, the regulatory mechanism of these risk factors in the pathogenesis of CSVD remains unclear. Therefore, developing effective CSVD prevention and treatment strategies is a difficult task. Investigators work hard to clarify the underlying mechanism and explore the therapeutic interventions of CSVD, so far, the results are still unsatisfactory.

In this Research Topic, we would like to gain an improved understanding of the pathogenesis of CSVD and to help in the development of new preventative and therapeutic approaches for CSVD.

This Research Topic welcomes all original articles, reviews and reports related, but not limited to, the following sub-topics:
- The role of neuronal and glial inflammation in the pathogenesis of CSVD
- The role of endothelial function in the pathogenesis of CSVD
- The role of oxidative stress in the pathogenesis of CSVD
- The regulatory roles of genes in the pathogenesis of CSVD, such as APOE and NOTCH3 genes
- The proteins that related to the pathogenesis of CSVD, such as cerebral amyloid-╬▓ and tau protein
- Investigate the preventive and therapeutic methods of CSVD
- Identify key risk factors of CSVD by epidemiological investigations


Keywords: Cerebral small vessel disease (CSVD), Pathogenesis, Preventive and Therapeutic Methods


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Cerebral small vessel disease (CSVD) is caused by several different pathophysiologic mechanisms that mostly affect the small arteries, arterioles, venules, and capillaries of the brain. It is a common cause of stroke and dementia in elderly people, accounting for up to nearly half of all dementias and 25-30% of all strokes worldwide.

The pathogenesis of CSVD is still unclear. Although many risk factors of CSVD have been identified, including hypertension, diabetic mellitus, dyslipidemia, endothelial dysfunction, inflammation, oxidative stress, cerebral amyloid angiopathy, and several genetic disorders. However, the regulatory mechanism of these risk factors in the pathogenesis of CSVD remains unclear. Therefore, developing effective CSVD prevention and treatment strategies is a difficult task. Investigators work hard to clarify the underlying mechanism and explore the therapeutic interventions of CSVD, so far, the results are still unsatisfactory.

In this Research Topic, we would like to gain an improved understanding of the pathogenesis of CSVD and to help in the development of new preventative and therapeutic approaches for CSVD.

This Research Topic welcomes all original articles, reviews and reports related, but not limited to, the following sub-topics:
- The role of neuronal and glial inflammation in the pathogenesis of CSVD
- The role of endothelial function in the pathogenesis of CSVD
- The role of oxidative stress in the pathogenesis of CSVD
- The regulatory roles of genes in the pathogenesis of CSVD, such as APOE and NOTCH3 genes
- The proteins that related to the pathogenesis of CSVD, such as cerebral amyloid-╬▓ and tau protein
- Investigate the preventive and therapeutic methods of CSVD
- Identify key risk factors of CSVD by epidemiological investigations


Keywords: Cerebral small vessel disease (CSVD), Pathogenesis, Preventive and Therapeutic Methods


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 November 2021 Abstract
14 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 November 2021 Abstract
14 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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