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The success of in utero cell transplantation depends on a deep understanding of stem cell biology, transplantation immunology, and maternal-fetal tolerance. ...

The success of in utero cell transplantation depends on a deep understanding of stem cell biology, transplantation immunology, and maternal-fetal tolerance.
In this Research Topic, we will review state of the art concepts in fetal stem cell transplantation, with the common goal of moving regenerative fetal therapies from animal models to the clinic.
Through research articles, mini-reviews, and perspective articles, we wish to divulge and summarize the latest science breakthroughs, regarding cell transplantation and gene delivery during the fetal period. Specifically, we will cover topics associated with 1)Hematopoiesis and In Utero Transplantation, 2)Mechanisms of Transplantation Tolerance, 3)In Utero Gene Therapy, Mesenchymal and Amniotic Fluid-Derived Cell Therapies, and 4) Maternal/Fetal/Neonatal Tolerance

We anticipate that the information presented and discussed in the Research Topics will increase the knowledge for the development of novel strategies to achieve therapeutic levels of engraftment in the fetus, and the identification of ways to safely translate these strategies to a wide range of clinical applications.

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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