Lessons Inborn Errors of Immunity Hold for Common Autoimmune and Autoinflammatory Disorders

There is a growing understanding of the clinical overlap between disorders of immune deficiency and disorders of autoimmunity and auto-inflammation. An atypical or treatment-refractory clinical presentation of autoimmunity may in fact signal an underlying congenital condition of primary immune dysregulation (an inborn error of immunity). Our growing ability to define such convergent and divergent patterns of immune dysregulation has the direct potential to improve patient care. Specifically, moving towards targeted immunomodulation based directly on an underlying genetic or functional immunophenotypic defect may reduce the use of unnecessary immunosuppression and provide more exacting therapeutic benefit to our patients.

In this Research Topic, we look to explore genetic, epidemiologic, functional immunophenotypic, and even therapeutic response overlap between conditions of primary immune dysregulation and more common conditions of autoimmunity and/or auto-inflammatory disease. We are also interested in work that may define unique clinical signatures of inborn errors of immunity within broader clinical presentations of autoimmunity and/or auto-inflammatory disease. We aim to include research that may define patterns of immunobiology convergent or divergent between more rare inborn errors of immunity and more common autoimmune and auto-inflammatory disorders. Furthermore, we aim to collect research discussing the epidemiologic factors and/or secondary genetic modifiers that may influence the clinical presentation of an inborn error of immunity. Finally, we welcome the submission of manuscripts that may define convergent or divergent patterns of immunomodulation response between more rare inborn errors of immunity and more common autoimmune and auto-inflammatory disorders.

In this Research Topic, we welcome the submission of Original Research, Review, Mini Review, Case Report, Clinical Trial, Perspective, and Opinion articles covering, but not limited to, the following sub-topics:

• Frequency of detecting inborn errors of immunity in common autoimmune and/or auto-inflammatory disorders.

• Unique clinical signatures of inborn errors of immunity in common autoimmune and/or auto-inflammatory disorders.

• Immunobiology convergent or divergent between inborn errors of immunity and common autoimmune and/or auto-inflammatory disorders.

• Epidemiologic factors that influence the clinical presentation of an inborn error of immunity, specifically towards the development of autoimmunity or auto-inflammatory disease.

• Compound genetic defects that influence the clinical presentation of an inborn error of immunity, specifically towards the development of autoimmunity or auto-inflammatory disease.

• Patterns of immunomodulation response convergent or divergent between inborn errors of immunity and common autoimmune and/or auto-inflammatory disorders.

Dr. Jocelyn Farmer received financial support from Bristol Myers Squibb. The other Topic Editors declare no competing interests with regard to the Research Topic subject.