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Scope
Patients with primary immunodeficiencies provide rare opportunities to study the impact of specific defective genes on the development and the regulation of the immune system in humans. In addition, impaired immune functions leading to primary immunodeficiencies often correlate with paradoxical autoimmune complications.Primary Immunodeficiencies focuses on all aspects of primary immunodeficiencies including the characterization of new syndromes, the identification of gene defects or hypomorphic alleles promoting disease, the report of unusual cases of known immunodeficiencies as well as the detailed analysis of specific immune compartment defects associated with primary immunodeficiencies. Animal models relevant to primary immunodeficiencies, as well as studies assessing the molecular mechanisms by which mutant proteins interfere with protein interaction or signaling, are also highly relevant to the mission of the section. Finally, Primary Immunodeficiencies aims at increasing communication and collaborations between clinicians and investigators to favor human translational and basic research. Indeed, understanding the mechanisms that lead to primary immunodeficiencies may suggest new approaches to control diseases and design more specific and sustained therapies.
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PMCID: all published articles receive a PMCID
Primary Immunodeficiencies welcomes submissions of the following article types: Case Report, Classification, Clinical Trial, Correction, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Protocols, Review, Systematic Review and Technology Report.
All manuscripts must be submitted directly to the section Primary Immunodeficiencies, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
Articles published in the section Primary Immunodeficiencies will benefit from the Frontiers impact and tiering system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a Frontiers Focused Review - a tier-climbing article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Immunology.
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