Frontiers in Immunology

Original Research

Published on 13 May 2026

Dynamic changes in peripheral blood lymphocyte subsets predict the efficacy and prognosis of immune checkpoint inhibitors in metastatic osteosarcoma

in Cancer Immunity and Immunotherapy

Longqing Li
Jinlei Liu
Yuan Zhao
Songtao Pang
Bin Zhang
Jia Wen
Yongkui Liu
Yi Zhang
Yan Zhang
Jiazhen Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1766639

151 views

Original Research

Published on 13 May 2026

Sex-specific reporting patterns and onset timing of immune-related adverse events associated with nivolumab and pembrolizumab: a dual-database pharmacovigilance analysis

in Cancer Immunity and Immunotherapy

Yu Bai
Hong Liu
Hao Meng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1837640

154 views

Perspective

Published on 13 May 2026

Divergent immune cascades activated by metabolic versus mechanical exercise intensity: revisiting cytokine heterogeneity in “moderate-intensity exercise”

in Cytokines and Soluble Mediators in Immunity

Jia-wen Wang
Jian-Jun Xun
Li-Na Jian

Frontiers in Immunology

doi 10.3389/fimmu.2026.1846052

159 views

Original Research

Published on 13 May 2026

Serum interleukin-6 as a neuroinflammatory biomarker across the spectrum of neurological disorders: a large-scale retrospective cohort study of 6,465 individuals

in Multiple Sclerosis and Neuroimmunology

Lingjun Zhao
Zhaoming Tang
Chengliang Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1825206

229 views

Original Research

Published on 13 May 2026

The significance of CEACAM60, a carcinoembryonic antigen (CEA) homolog, as a tumor antigen in the porcine cancer model

in Comparative Immunology

Jinsil Lee
Clara Cañas Crespo
Tim Hammacher
Andrei Lazar
Eva M Guenther
Marie Johne
Wiebke Weiß
Tung Huy Dau
Pavlo Maksimov
Krzysztof Flisikowski

Frontiers in Immunology

doi 10.3389/fimmu.2026.1813834

283 views

Review

Published on 13 May 2026

Convergent death programs in chronic obstructive pulmonary disease: how pyroptotic and ferroptotic crosstalk reshapes therapeutic paradigms

in Inflammation

Aisi Huang
Shiming Liu
Jiao Lan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1827181

186 views

Original Research

Published on 13 May 2026

Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics

in Cancer Immunity and Immunotherapy

Bohdana Chayen
Gal Dinstag
Omer Tirosh
Leon Gugel
Tuvik Beker
Tzivia Gottlieb
Anna Elia
Eli Pikarsky
Michal Lotem
Mordechai Avner

Frontiers in Immunology

doi 10.3389/fimmu.2026.1822422

244 views

Original Research

Published on 13 May 2026

Gallic acid exerts therapeutic effects on sciatica by reducing inflammatory responses through the regulation of NOX4-mediated oxidative stress

in Molecular Innate Immunity

Zenni Chen
Zifeng Zhuang
Shaozi Lin
Yuting Hao
Xiaokang Xie
Hongling Chen
Lan Lin
Yixuan Li
Lili Fan
Shiquan Chang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1748652

240 views

Original Research

Published on 13 May 2026

Refractory immune cytopenia successfully treated with mycophenolate mofetil in four adolescents with del22q11.2 syndrome

in Primary Immunodeficiencies

Cristina Cifaldi
Lucia Pacillo
Chiara Rossetti
Silvia Di Cesare
Michele La Manna
Veronica Santilli
Beatrice Rivalta
Elisabetta Lembo
Mattia Moratti
Lucia Colucci

Frontiers in Immunology

doi 10.3389/fimmu.2026.1819182

247 views

Original Research

Published on 13 May 2026

miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity

in Inflammation

Harshita Shailesh
Mohamed Nadhir Djekidel
Safa Noor
Lena Hayati
Stefan Worgall
Souhaila Al Khodor
Ibrahim Janahi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1792996

169 views

Original Research

Published on 13 May 2026

Generation of functional canine TIL products for solid tumors

in Comparative Immunology

Kay M. Foos
Veethika Pandey
Michael W. Jennings
Daniel J. Powell
Nicola J. Mason

Frontiers in Immunology

doi 10.3389/fimmu.2026.1810955

176 views

Mini Review

Published on 13 May 2026

Wnt signaling as a regulator of memory T cells: implications for CAR-T cell therapy

in Cancer Immunity and Immunotherapy

Tatiana Fourfouris
Ki Jun Lee
Samantha Hurwitz
Asher Ahdoot
Alexander Lee
Maiah Zarrabi
Michael Kahn
Yong-Mi Kim

Frontiers in Immunology

doi 10.3389/fimmu.2026.1843548

189 views

Review

Published on 13 May 2026

Neutrophil extracellular traps in gout: from immune defense to pathological dynamic equilibrium

in Inflammation

Fangfang Wang
Ning Tie
Yong Jin
Hongbin Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1826191

205 views

Review

Published on 13 May 2026

Peripheral nerve remodeling in the tumor microenvironment: neuro-immune crosstalk, molecular mechanisms, and precision therapeutic

in Cancer Immunity and Immunotherapy

Huiying Liu
Xunjun Li
Jiang Yu
Tao Chen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1789297

174 views

Original Research

Published on 13 May 2026

Lactylation-mediated remodelling of the breast cancer microenvironment: single-cell multidimensional analysis and prognostic model construction

in Cancer Immunity and Immunotherapy

Jiaxin Chen
Yixue Hao
Yinghua Feng
Yongjing Dai
Haoyuan Shi
Li Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1747043

277 views

Original Research

Published on 13 May 2026

Comparative effectiveness of budesonide EC and telitacicept in proteinuria and eGFR trajectories in IgA nephropathy: a retrospective cohort study

in B Cell Biology

Xingsheng Zuo
Yaqin Wang
Fangfang Ma
Xianyuan Zhu
Chenglong Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2026.1821774

230 views

Review

Published on 13 May 2026

Beyond the usual suspects: rethinking post-stroke immunosuppression

in Inflammation

Laia Ascaso-Vidal
Alba Simats
David Brea

Frontiers in Immunology

doi 10.3389/fimmu.2026.1824573

179 views

Review

Published on 13 May 2026

Antimicrobial proteins and peptides in pregnancy: Guardians of the maternal–fetal frontier

in Molecular Innate Immunity

Andrea Olmos-Ortiz
Bruno Rivas-Santiago
Oscar González-Muñíz
Daniel Ortuño-Sahagún
Ismael Mancilla-Herrera
Cecilia Helguera-Repetto
Verónica Zaga-Clavellina

Frontiers in Immunology

doi 10.3389/fimmu.2026.1783841

149 views

Mini Review

Published on 13 May 2026

Serum inflammatory cytokines in the progression of depression

in Cytokines and Soluble Mediators in Immunity

Qing Feng
Zhen Yuan
Qi An
Kang Wang
Xiaohui Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1808989

282 views

Review

Published on 13 May 2026

B7-H4: a multifaceted immune checkpoint and oncoprotein in cancer biology and immunotherapy

in Cancer Immunity and Immunotherapy

Chunyu Zhang
Zhiwei Miao
Jingjing Cao
Xiaoyu Wang
Tongguo Shi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1837397

129 views

Brief Research Report

Published on 13 May 2026

Serplulimab combined with gemcitabine, nab-paclitaxel, and stereotactic body radiotherapy versus gemcitabine and nab-paclitaxel as first-line treatment for recurrent or metastatic pancreatic ductal adenocarcinoma: a randomized, open-label, multicenter, phase III clinical trial (WGOG-PAN 006/ICSBR-2)

in Cancer Immunity and Immunotherapy

Xin Wang
Pei Zhang
Dan Cao
Huanji Xu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1817221

190 views

Original Research

Published on 13 May 2026

Buprenorphine extended-release (Ethiqa XR) impacts the immunological response in mice exposed to aerosolized Burkholderia pseudomallei or Yersinia pestis

in Comparative Immunology

Carlos I. Rodriguez
Christopher P. Klimko
Michael L. Davies
Jennifer L. Dankmeyer
Nathaniel O. Rill
Melissa Hunter
Brian A. Smith
Taloria K. Wheeler
Wendy M. Webster-Zahnow
Andre M. Swamotz

Frontiers in Immunology

doi 10.3389/fimmu.2026.1823747

339 views

Original Research

Published on 13 May 2026

Mesenchymal stem cell alleviate concanavalin A-induced hepatitis via immune reprogramming and complement regulation

in Immunological Tolerance and Regulation

Hanpeng Luo
Bing Liu
Yaqin Li
Peng Cui
Tao Zhou
Cai Ye
Can Wu
Junchang Wu
Yu Wang
Wei V. Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1809194

313 views

Original Research

Published on 13 May 2026

Hyperthermia enhances the efficacy of PD-1 inhibitor plus chemotherapy in PD-L1 CPS-negative advanced gastric cancer

in Cancer Immunity and Immunotherapy

Weihang Li
Xin Sun
Ping Li
Ting Wang
Panling Xu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1795363

160 views

52,166 articles

articles

Dynamic changes in peripheral blood lymphocyte subsets predict the efficacy and prognosis of immune checkpoint inhibitors in metastatic osteosarcoma

Sex-specific reporting patterns and onset timing of immune-related adverse events associated with nivolumab and pembrolizumab: a dual-database pharmacovigilance analysis

Divergent immune cascades activated by metabolic versus mechanical exercise intensity: revisiting cytokine heterogeneity in “moderate-intensity exercise”

Serum interleukin-6 as a neuroinflammatory biomarker across the spectrum of neurological disorders: a large-scale retrospective cohort study of 6,465 individuals

The significance of CEACAM60, a carcinoembryonic antigen (CEA) homolog, as a tumor antigen in the porcine cancer model

Convergent death programs in chronic obstructive pulmonary disease: how pyroptotic and ferroptotic crosstalk reshapes therapeutic paradigms

Prediction of clinical outcomes of advanced cutaneous squamous cell carcinoma to PD-1 inhibition directly from histopathology slides using inferred transcriptomics

Gallic acid exerts therapeutic effects on sciatica by reducing inflammatory responses through the regulation of NOX4-mediated oxidative stress

Refractory immune cytopenia successfully treated with mycophenolate mofetil in four adolescents with del22q11.2 syndrome

miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity

Generation of functional canine TIL products for solid tumors

Wnt signaling as a regulator of memory T cells: implications for CAR-T cell therapy

Neutrophil extracellular traps in gout: from immune defense to pathological dynamic equilibrium

Peripheral nerve remodeling in the tumor microenvironment: neuro-immune crosstalk, molecular mechanisms, and precision therapeutic

Lactylation-mediated remodelling of the breast cancer microenvironment: single-cell multidimensional analysis and prognostic model construction

Comparative effectiveness of budesonide EC and telitacicept in proteinuria and eGFR trajectories in IgA nephropathy: a retrospective cohort study

Beyond the usual suspects: rethinking post-stroke immunosuppression

Antimicrobial proteins and peptides in pregnancy: Guardians of the maternal–fetal frontier

Serum inflammatory cytokines in the progression of depression

B7-H4: a multifaceted immune checkpoint and oncoprotein in cancer biology and immunotherapy

Serplulimab combined with gemcitabine, nab-paclitaxel, and stereotactic body radiotherapy versus gemcitabine and nab-paclitaxel as first-line treatment for recurrent or metastatic pancreatic ductal adenocarcinoma: a randomized, open-label, multicenter, phase III clinical trial (WGOG-PAN 006/ICSBR-2)

Buprenorphine extended-release (Ethiqa XR) impacts the immunological response in mice exposed to aerosolized Burkholderia pseudomallei or Yersinia pestis

Mesenchymal stem cell alleviate concanavalin A-induced hepatitis via immune reprogramming and complement regulation

Hyperthermia enhances the efficacy of PD-1 inhibitor plus chemotherapy in PD-L1 CPS-negative advanced gastric cancer