Frontiers in Immunology

Original Research

Published on 28 Jan 2026

Coagulation-related genes COL3A1 and MMP1 influence the development of osteoarthritis and the surrounding immunological environment

in Inflammation

Liangkun Huang
Xuezhong Wang
Zijie Pei
Ze Zhang
Fengpo Sun
Liangyuan Wen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1759281

Review

Published on 28 Jan 2026

Decoding the lncRNA-miRNA-mRNA network in sepsis-induced lung injury: from pathogenesis to extracellular vesicle-based therapy

in Inflammation

Yating Wei
Weiye Gong
Yuhua Wei
Xiaohong Jiang
Chaoqian Li
Rongzong Ye

Frontiers in Immunology

doi 10.3389/fimmu.2026.1701440

115 views

Original Research

Published on 28 Jan 2026

A skin isolate of Micrococcus luteus negates the Staphylococcus aureus-induced release of type 2 cytokines from keratinocytes

in Microbial Immunology

Abigail E. Elias
Joanne L. Pennock
Andrew J. McBain
Emma-Jayne Keevill
Catherine A. O’Neill

Frontiers in Immunology

doi 10.3389/fimmu.2026.1711723

153 views

Original Research

Published on 28 Jan 2026

Prognostic value of lymphatic vessel density in the capsule of early-stage hepatocellular carcinoma: implications for postoperative recurrence risk

in Cancer Immunity and Immunotherapy

Jin Li
Yu-Bo Liang
Xing-Ming Chen
Zhi-Yan Ou
Qing-Bo Wang
Wan-Ling Luo
Yawhan Lakang
Zi-Sheng Yang
Jin-Xiang Zuo
Yu-Kai Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1714314

Mini Review

Published on 28 Jan 2026

Spatially resolved tryptophan–kynurenine niches in HNSCC: immunometabolic microdomains and therapeutic implications

in Cancer Immunity and Immunotherapy

Wanchen Ning
Shaohong Huang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1756010

Editorial

Published on 28 Jan 2026

Editorial: Systems Immunology and Translational Research in Infectious Diseases

in Systems Immunology

Mariana Araújo-Pereira
Caian L. Vinhaes
Artur T. L. Queiroz
Bruno B. Andrade

Frontiers in Immunology

doi 10.3389/fimmu.2026.1791482

Original Research

Published on 28 Jan 2026

B-cell epitope mapping and characterization of antibody responses to recombinant PvRipr in malaria-exposed individuals

in Parasite Immunology

Isabela Ferreira Soares
Cinthia Magalhães Rodolphi
Ana Luiza Carneiro Alencar
Ada da Silva Matos
Rodrigo Nunes Rodrigues-da-Silva
Barbara de Oliveira Baptista
Rodrigo Medeiros Martorano
Hugo Amorim dos Santos de Souza
Evelyn Kety Pratt Riccio
Jenifer Peixoto de Barros

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710869

174 views

Review

Published on 28 Jan 2026

Role of IL-32 in RA pathology and potential as a drug target

in Cytokines and Soluble Mediators in Immunity

Hongliang Zhang
Qingyuan Chen
Hui Yu
Mingzi Zhu
Xiaoqing Zhang
Xin Fu
Songquan Wu
Guangli Wang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1696081

117 views

Original Research

Published on 28 Jan 2026

Identification and validation of γ-Linolenic acid as a natural FABP5 inhibitor in hepatocellular carcinoma through deep learning and experimental approaches

in Cancer Immunity and Immunotherapy

Yuan An
Hongyu Liu
Wei Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1700347

114 views

Systematic Review

Published on 28 Jan 2026

Clinical characteristics, management, and prognosis of pembrolizumab-induced immune-related oral mucositis

in Cancer Immunity and Immunotherapy

Liuxian Yu
Jun Li
Yaxi Tang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1710588

135 views

Original Research

Published on 28 Jan 2026

Transcriptome and single-cell RNA sequencing analysis with 101 machine learning combinations and experimental verification reveals the mechanism of action of mannose metabolism in bladder cancer

in Cancer Immunity and Immunotherapy

Anhong Li
Kaile Zhao
Tianjiao Wang
Guangyue Shi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1710823

127 views

Review

Published on 28 Jan 2026

Gasotransmitters bridging tumor biology and immunity: from pathophysiological insights to therapeutic potential

in Cancer Immunity and Immunotherapy

Giulia Ballerini
Andrea Balboni
Valentina Garlatti
Martina Incerti
Antonio Sica
Francesca Maria Consonni

Frontiers in Immunology

doi 10.3389/fimmu.2026.1671203

Original Research

Published on 28 Jan 2026

B cell phenotypes and antibody signatures associate with interpatient variation in the lung adenocarcinoma tumor microenvironment

in Cancer Immunity and Immunotherapy

Kamille M. Rasche
David Tieri
Samantha M. Morrissey
Hong Li
Fan Zhang
William S. Gibson
Easton E. Ford
Uddalok Jana
Melissa L. Smith
Jun Yan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739637

355 views

Original Research

Published on 28 Jan 2026

Apigenin ameliorates postoperative inflammation and accelerates wound healing in a rat model of perianal abscess by targeting the JAK1/STAT3 pathway in macrophages

in Inflammation

Ruixue Dai
Liangliang Cao
Jiahui Ren
Jingru Liu
Kexin Zhu
Peidong Chen
Weifeng Yao
Xuelong Zhao
Beihua Bao
Li Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2026.1726917

141 views

Opinion

Published on 28 Jan 2026

Altered genome induced immune response of iPSCs

in Alloimmunity and Transplantation

Jordi Requena Osete
Belén Álvarez Palomo
Michael J. Edel

Frontiers in Immunology

doi 10.3389/fimmu.2026.1751499

449 views

Case Report

Published on 28 Jan 2026

Case Report: Characterization of a RAC2 R68W homozygous activating mutation causing combined immune deficiency

in Primary Immunodeficiencies

Aléhandra Desjardins
Louis Marois
Ágnes Donkó
Guilhem Cros
Marc-Antoine Bédard
Marie-Lorna Paul
Amy P. Hsu
Emma Darbinian
Géraldine Gosse
Thomas L. Leto

Frontiers in Immunology

doi 10.3389/fimmu.2026.1723142

143 views

Original Research

Published on 28 Jan 2026

A machine learning-driven prognostic model based on peripheral blood lymphocyte subsets in osteosarcoma

in Cancer Immunity and Immunotherapy

Longqing Li
Jinlei Liu
Songtao Pang
Yuan Zhao
Yimeng Wang
Jia Wen
Yongkui Liu
Yi Zhang
Yan Zhang
Jiazhen Li

Frontiers in Immunology

doi 10.3389/fimmu.2026.1733518

104 views

Original Research

Published on 28 Jan 2026

The metastasis landscape of Clonorchis sinensis-associated hepatocellular carcinoma: an integrated multi-omics and clinical study

in Parasite Immunology

Lingling Zhou
Lin Sun
Xuhang Huang
Junxian Chen
Taijun Huang
Yulong Xu
Xiaorong Luo
Caibiao Wei
Fengfei Liu
Xiaolan Pan

Frontiers in Immunology

doi 10.3389/fimmu.2026.1723156

228 views

Original Research

Published on 28 Jan 2026

Safety and efficacy of B-cell therapy in older people with multiple sclerosis

in Multiple Sclerosis and Neuroimmunology

Turlough Montague
Yuuki Kang
Karen Thomas
Nicole Burke Simpson
Celia Miller
Sophie Chatterton
Ariadna Fontes Villalba
John Parratt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1699550

487 views

Review

Published on 28 Jan 2026

Kidney transplantation beyond immunosuppression: shifting the focus from graft survival to patient health

in Alloimmunity and Transplantation

Gabriella Moroni
Francesco Reggiani
Claudio Ponticelli

Frontiers in Immunology

doi 10.3389/fimmu.2026.1738675

268 views

Original Research

Published on 28 Jan 2026

The stem of Schisandra chinensis and Schisandrin B alleviated DNCB-induced atopic dermatitis in mice by inhibiting the NF-κB pathway

in Inflammation

Cai Ye
Yijie Liu
Yue Li
Zan Li
Liyuan Sui
Jiwen Cui
Zihao Jiang
Jinlian Li
Jianjun Song
Jiguang Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1725312

149 views

Original Research

Published on 28 Jan 2026

Prognostic impact of advanced lung cancer inflammation index and tumor load index in esophageal squamous cell carcinoma after neoadjuvant immunochemotherapy

in Cancer Immunity and Immunotherapy

Yizhou Huang
Maohui Chen
Zhenyuan Yang
Yongcong Zhang
Chuanquan Lin
Shuliang Zhang
Taidui Zeng
Jun Yu
Chun Chen
Bin Zheng

Frontiers in Immunology

doi 10.3389/fimmu.2026.1724061

129 views

Original Research

Published on 28 Jan 2026

The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis

in Molecular Innate Immunity

Yamin Song
Fangzheng Guo
Huiting Dai
Xiaoyu Zhou
Sihang Dong
Hui Zhang
Zhongqing Qian
Baiqing Li
Xiaojing Wang
Tao Xu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1707304

133 views

Original Research

Published on 28 Jan 2026

Prognostic gene screening and experimental validation in renal clear cell carcinoma based on spatial transcriptomics and single-cell sequencing

in Cancer Immunity and Immunotherapy

Cong Fu
Lin Sun
Tong Zhou
Yanzhi Bi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1699883

181 views

49,357 articles

articles

Coagulation-related genes COL3A1 and MMP1 influence the development of osteoarthritis and the surrounding immunological environment

Decoding the lncRNA-miRNA-mRNA network in sepsis-induced lung injury: from pathogenesis to extracellular vesicle-based therapy

A skin isolate of Micrococcus luteus negates the Staphylococcus aureus-induced release of type 2 cytokines from keratinocytes

Prognostic value of lymphatic vessel density in the capsule of early-stage hepatocellular carcinoma: implications for postoperative recurrence risk

Spatially resolved tryptophan–kynurenine niches in HNSCC: immunometabolic microdomains and therapeutic implications

Editorial: Systems Immunology and Translational Research in Infectious Diseases

B-cell epitope mapping and characterization of antibody responses to recombinant PvRipr in malaria-exposed individuals

Role of IL-32 in RA pathology and potential as a drug target

Identification and validation of γ-Linolenic acid as a natural FABP5 inhibitor in hepatocellular carcinoma through deep learning and experimental approaches

Clinical characteristics, management, and prognosis of pembrolizumab-induced immune-related oral mucositis

Transcriptome and single-cell RNA sequencing analysis with 101 machine learning combinations and experimental verification reveals the mechanism of action of mannose metabolism in bladder cancer

Gasotransmitters bridging tumor biology and immunity: from pathophysiological insights to therapeutic potential

B cell phenotypes and antibody signatures associate with interpatient variation in the lung adenocarcinoma tumor microenvironment

Apigenin ameliorates postoperative inflammation and accelerates wound healing in a rat model of perianal abscess by targeting the JAK1/STAT3 pathway in macrophages

Altered genome induced immune response of iPSCs

Case Report: Characterization of a RAC2 R68W homozygous activating mutation causing combined immune deficiency

A machine learning-driven prognostic model based on peripheral blood lymphocyte subsets in osteosarcoma

The metastasis landscape of Clonorchis sinensis-associated hepatocellular carcinoma: an integrated multi-omics and clinical study

Safety and efficacy of B-cell therapy in older people with multiple sclerosis

Kidney transplantation beyond immunosuppression: shifting the focus from graft survival to patient health

The stem of Schisandra chinensis and Schisandrin B alleviated DNCB-induced atopic dermatitis in mice by inhibiting the NF-κB pathway

Prognostic impact of advanced lung cancer inflammation index and tumor load index in esophageal squamous cell carcinoma after neoadjuvant immunochemotherapy

The mechanism regulating the cytotoxicity of γδ T cells activated by mycobacterium tuberculosis heat-resistant antigen based on RNA-seq analysis

Prognostic gene screening and experimental validation in renal clear cell carcinoma based on spatial transcriptomics and single-cell sequencing