Frontiers in Immunology

Original Research

Accepted on 10 Oct 2025

Knockdown of TOP2A Reverses Cisplatin 1 Resistance in Ovarian Cancer by Inhibiting 2 EMT via Ferroptosis Mediated by the 3 TP53/GPX4/SLC7A11 Axis 4

in Cancer Immunity and Immunotherapy

Liu Xinyue
Junxia Wang
Yangyu Liu
Yan Han
Zhichao Qin
Yu Wang
Shanxiang Gao
Xinghua Li
Yuping Suo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675373

Original Research

Accepted on 10 Oct 2025

Targeting Cystatin F Activation Enhances NK Cell Cytotoxicity in Glioblastoma Models

in Cancer Immunity and Immunotherapy

Emanuela Senjor
Anamarija Habič
Urban Švajger
Ana Mitrović
Matic Proj
Andrej Porčnik
Borut Prestor
Miha Jerala
Matic Bošnjak
Stanislav Gobec

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708281

Original Research

Accepted on 10 Oct 2025

B cell receptor repertoire reconstitution in patients with neuromyelitis optica spectrum disorder receiving B-cell depletion therapy

in B Cell Biology

Hyo Jae Kim
Wangyong Shin
Dayoung Seo
Inhye Jang
Jihong Ryu
Lynkyung Choi
Jinhee Kim
Hyunjin Kim
Young-Min Lim
Eun-Jae LEE

Frontiers in Immunology

doi 10.3389/fimmu.2025.1673508

Original Research

Accepted on 10 Oct 2025

Single-Cell Transcriptomics Unravels the Early Immune Landscape of Renal Allograft Rejection and Nominates Ccl3-Ccr5 as a Therapeutic Target

in Alloimmunity and Transplantation

Fanchao Wei
Zhaoxiang Wang
Ruochen Qi
Jingliang Zhang
Shichao Han
Changhong Shi
Tong Lu
Zhite Zhao
Zhengxuan Li
Lang Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1663251

Original Research

Accepted on 10 Oct 2025

Identification of CAF signature genes and construction of CAF-based risk signature in hepatocellular carcinoma by multi-omics analysis

in Inflammation

Wenchen Qian
Kezhi Wu
Bowen Ni
Haojie Zheng
Yawei Liu
Manlan Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1690174

Original Research

Accepted on 10 Oct 2025

Framework humanization enhances GM3(Neu5Gc)-targeting CAR-T cell function by reducing tonic signaling

in Cancer Immunity and Immunotherapy

Jiaxin Tu
Xinyu Li
Yuge Zhu
Shance Li
Guanyu Zhang
You He
Chaoting Zhang
Zheming Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697732

Original Research

Accepted on 10 Oct 2025

Loss of Two-pore channel 2 enhances CD8+ T cell cytotoxicity and directly impairs tumour growth via MAPK axis in HCC

in Cancer Immunity and Immunotherapy

Lina Ouologuem
Anna Kübler
Sarah Ouologuem
Amar Hadzic
Jan B. Stöckl
Anna Chiara Siciliano
Stefania Forciniti
Salvatore Nigro
Helena Iuele
Valentina Onesto

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668066

Original Research

Accepted on 10 Oct 2025

Humoral immune activation within tertiary lymphoid structures is correlated with poor outcomes in oral lichen planus and lichenoid lesions

in Mucosal Immunity

Xiaojie Yang
Annan Dai
Yirao Lai
Pan Lei
Yiwen Deng
Xuemin Shen
Xiaozhe Han
Lei Sun
Yufeng Wang
Guoyao Tang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1667976

Editorial

Accepted on 10 Oct 2025

Editorial: Mucosal Microbiota Immunomodulation of the Gut-Lung Axis: From Mechanistic Insights to Therapeutic Horizons

in Mucosal Immunity

Yuseok Moon
Susanta Pahari
Shikha Negi
Evelyn Tsantikos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1721724

Original Research

Accepted on 10 Oct 2025

Expression of NEAT1 induced by influenza virus infection is regulated by activated STAT3 and contributes to STAT3-mediated antiviral immunity

in Molecular Innate Immunity

Rongrong Gu
Erying Xu
Jingjie Hong
Liqing Fan
Shasha Liu
Ji-Long Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693884

Original Research

Accepted on 10 Oct 2025

The Role of NFKB1 and NFKBIA in Immunoglobulin A Vasculitis

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Joao Carlos Batista Liz
María Sebastián Mora-Gil
Mónica Renuncio García
María Teresa Leonardo
Ana Peñalba
Ligia Gabrie
Rafael Gálvez
Luis Martín-Penagos
Javier Narvaez
Belén Sevilla Pérez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692908

Review

Accepted on 10 Oct 2025

NETs: A new target for autoimmune disease

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Xiaoyi Jia
Ran Tang
Zhifang Qin
Min Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646527

Original Research

Accepted on 10 Oct 2025

The Peptide Genomic Therapy Increases Antibacterial Immunity and Survival in Sepsis by Reprograming the Gene Orthologs of Human Immunodeficiencies in the Spleen and Lungs

in Molecular Innate Immunity

Jacek Hawiger
Huan Qiao
Jozef Zienkiewicz
Yan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635081

Original Research

Accepted on 10 Oct 2025

Construction of a prognostic model based on palmitoylation-related lncRNAs for assessing drug benefits in breast cancer

in Vaccines and Molecular Therapeutics

Yan Wang
Mengsi Zhang
Yuqin Zhou
Zaozhuo Li
Xinglin Yi
Lin Ren
Yi Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656593

Editorial

Accepted on 10 Oct 2025

Editorial: Response/Resistance to PD-1 Axis Inhibitors: Focus on the Tumor Microenvironment

in Cancer Immunity and Immunotherapy

Parmees Fazeli
Diba Yaghoubi
Ioannis Vathiotis
Arutha Kulasinghe
Thazin N Aung

Frontiers in Immunology

doi 10.3389/fimmu.2025.1720955

Editorial

Accepted on 10 Oct 2025

Editorial: The Immunological Effects of Respiratory Viruses during Pregnancy and Breastfeeding

in Viral Immunology

Stella Liong
Christopher Choy
Stavros Selemidis
Bahaa Abu-Raya
Domenico Umberto De Rose

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715204