Frontiers in Immunology | Primary Immunodeficiencies

Brief Research Report

Published on 16 Sep 2025

Immunogenetic investigation of WAS patients revealing impaired IL-6/STAT3 signaling in T cells

in Primary Immunodeficiencies

Firas Bouzakoura
Najla Mekki
Monia Ben Khaled
Ines Maaloul
Aicha Ben Taieb
Amal Zammeli
Meriem Ben-Ali
Mariem Tira
Ansem Ben-Hammadi
Thouraya Kamoun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602942

966 views

Original Research

Published on 15 Sep 2025

First report from the Czech national registry of inborn errors of immunity (2012–2025)

in Primary Immunodeficiencies

Zita Chovancova
Eva Hlavackova
Roman Hakl
Tomas Milota
Pavlina Kralickova
Ivana Malkusova
Beata Hutyrova
Michaela Safarova
Jana Vydlakova
Dalibor Jilek

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653685

638 views

Case Report

Published on 12 Sep 2025

Activated PI3K-δ syndrome presenting with cervical lymphadenopathy in a pediatric patient: a case report and review of the literature

in Primary Immunodeficiencies

Zhiwei Huang
Yaping Wang
Ruoying Wei
Hui Ding
Lian Du
Xiaomei Yang
Fu Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622764

1,326 views

Original Research

Published on 12 Sep 2025

Two cases of combined immunodeficiency with ITPR3 mutations presenting with life-threatening severe EBV-associated hemophagocytic lymphohistiocytosis

in Primary Immunodeficiencies

Lang Yu
Yulin Li
Liwen Zhang
Wenhui Li
Ming Sun
Yunfei An
Hao Xiong
Peina Jin
Xiaodong Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653662

1,202 views

Original Research

Accepted on 08 Sep 2025

CLINICAL, IMMUNOLOGICAL, MOLECULAR CHARACTERISTICS AND OUTCOMES OF STEM CELL TRANSPLANTATION IN ZAP70 DEFICIENCY: A SINGLE-CENTER EXPERIENCE

in Primary Immunodeficiencies

Fai Alqahtani
Azhar Alshaqaq
Bandar Al-Saud
Nora Alrumayyan
Reem Walid Mohammed
Rand K. Arnaout
Sahar Elshorbagi
sultan albuhairi
Ali Al-Ahmari
Mouhab Ayas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656240

1,045 views

Original Research

Accepted on 08 Sep 2025

Impact of CMV latency on T-cell responses to COVID-19 vaccination among predominantly antibody deficient patients

in Primary Immunodeficiencies

Trinidad Alba-Cano
Roberto Alonso
Héctor Balastegui
Luz Yadira Bravo-Gallego
Paloma Sánchez-Mateos
Mónica Martín-López
Juana Gil-Herrera

Frontiers in Immunology

doi 10.3389/fimmu.2025.1659259

1,109 views

Original Research

Published on 05 Sep 2025

A novel homozygous frameshift mutation likely causing nonsense-mediated mRNA decay in an Algerian kindred with CD19 complex deficiency

in Primary Immunodeficiencies

Brahim Belaid
Koon-Wing Chan
Lydia Lamara Mahammed
Daniel Leung
Sara Makhloufi
Fadila Bendaoud
Hassiba Sakhri
Lilya Meriem Berkani
Ines Allam
Fatma Merah

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634146

2,515 views

Case Report

Published on 04 Sep 2025

Case report: anti-IL-6 autoantibodies in a patient with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome

in Primary Immunodeficiencies

Tiziana Lorenzini
Lars Malmström
Ola Sabet
Samantha Milanesi
Diana Tintor
Severin Walser
Julius Köppen
Maarja Soomann
Mathias Hauri-Hohl
Seraina Prader

Frontiers in Immunology

doi 10.3389/fimmu.2025.1660161

1,273 views

Original Research

Accepted on 03 Sep 2025

Clinical and Immunological Spectrum of MHC Class I Deficiency: Insights from a Long-Term Cohort with Two Novel Mutations

in Primary Immunodeficiencies

Şule Haskologlu
Kamile Aydan Ikinciogullari
Candan Islamoglu
Sevgi Kostel Bal
Deniz Bayrakoglu
Serife Erdem
Ceren Karahan
Omur Ardeniz
Caner Aytekin
Aylin Heper

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675097

722 views

Case Report

Published on 02 Sep 2025

Case Report: Hematopoietic stem cell transplantation in an adult patient with X-linked agammaglobulinemia and severe refractory enteropathy

in Primary Immunodeficiencies

Paula Teresa López-León
Marta Dafne Cabañero-Navalon
Victor Garcia-Bustos
Francisco Giner
Héctor Balastegui Martín
Pedro Asensi Cantó
Juan Montoro Gómez
Olga Seguí-Cotano
María Argente Pla
Pedro Moral Moral

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662016

776 views

Case Report

Accepted on 30 Aug 2025

Novel UNC93B1 variant causes rheumatoid arthritis and interstitial pneumonia

in Primary Immunodeficiencies

Tingyan He
Junbin Ou
Lijuan Huang
Xinyi Zhou
Linlin Wang
Xiaolin Li
Yang Jun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671984

1,650 views

Case Report

Published on 29 Aug 2025

Case Report: X-linked agammaglobulinemia with progressive neurodegeneration from immunological to neurological implications

in Primary Immunodeficiencies

Xiaoyi Chen
Hao Gu
Yurong Piao
Yanli Ma
Yiran Zhao
Huawei Mao
Yuan Wang
Jie Deng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1611748

713 views

Opinion

Published on 28 Aug 2025

Opinion: the evolving understanding of polygenic common variable immunodeficiency-like disorders

in Primary Immunodeficiencies

Rohan Ameratunga
Euphemia Yee Leung
Hilary J. Longhurst
Klaus Lehnert
See-Tarn Woon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1618482

1,203 views

Original Research

Accepted on 25 Aug 2025

CXCR4 Antagonism Corrects Neutrophil Abnormalities and Reduces Pneumonia Severity in a Pharmacological Mouse Model of CXCR2 Loss-of-Function-Mediated Neutropenia

in Primary Immunodeficiencies

Chi Huu Nguyen
Katarina Zmajkovicova
Angelina Sekirnik
Sarah Taplin
Myriam Defontis
Jacob Bledsoe
Art G Taveras
Lars Karlsson
Robert Johnson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1658987

963 views

Original Research

Published on 22 Aug 2025

Prevalence and clinical implications of major and minor ANCAs in Tunisian (North African) patients with systemic lupus erythematosus

in Primary Immunodeficiencies

Zeineb Meddeb
Houssem Abida
Dhouha Krir
Ahlem Ben Hmid
Raja Aouaidia
Cherifa Abdelkéfi
Yosra Nasri
Ines Ben Sghaier
Hayet Kebaier
Samar Samoud

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657670

1,175 views

Case Report

Published on 20 Aug 2025

Case Report: A novel CXCR4 variant (p.S341Y) in a family with a pathogenic NFKB1 variant and variable clinical manifestations

in Primary Immunodeficiencies

Melis Yilmaz
Katarina Zmajkovicova
Rahim Z. Miller
Grace Blair
Maryssa Ellison
Boglarka Ujhazi
Maria Chitty Lopez
Joseph F. Dasso
Jacob R. Bledsoe
Krisztian Csomos

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641122

1,294 views