Frontiers in Immunology | Primary Immunodeficiencies

Original Research

Published on 05 Jun 2025

A survey of diagnosis and therapy of inborn errors of immunity among practice-based physicians and clinic-based pneumologists and hemato-oncologists

in Primary Immunodeficiencies

Thomas Lehrnbecher
Alexandra Russo
Gernot Rohde

Frontiers in Immunology

doi 10.3389/fimmu.2025.1597635

201 views

Original Research

Accepted on 02 Jun 2025

Рrospective multicenter study of treatment efficacy, safety, and quality of life in a large cohort of patients with inborn errors of immunity receiving subcutaneous immunoglobulin

in Primary Immunodeficiencies

Asmik Avedova
Elena Deripapa
Yulia Rodina
Anna A Mukhina
Elena LATYSHEVA
Daria Yukhacheva
Vasily Burlakov
Nellie Kan
Daria Bogdanova
Anna Moiseeva

Frontiers in Immunology

doi 10.3389/fimmu.2025.1598491

123 views

Original Research

Accepted on 02 Jun 2025

A Norwegian cohort with STAT1-related diseasefurther expanding the clinical phenotype

in Primary Immunodeficiencies

Karen Helene Bronken Martinsen
Torstein Øverland
Asbjørg Stray-Pedersen
Tore Gunnar Abrahamsen
Børre Fevang
Hans Christian Erichsen Landsverk

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620291

Original Research

Published on 02 Jun 2025

Dual variants of uncertain significance in a case of hyper-IgM syndrome: implications for diagnosis and management

in Primary Immunodeficiencies

Nourhen Agrebi
Rafah Mackeh
Mohamed Alsabbagh
Asha Elmi
Amnah A. Al-Marri
Satanay Z. Hubrack
Saleema C. Purayil
Mohammed Yousuf Karim
Amel Hassan
Bernice Lo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1594636

470 views

Case Report

Published on 30 May 2025

Case Report: Multiple peripheral nerve demyelinating lesions and cerebrovascular injury which resulted in extensive cerebral infarction in a XLP1 patient without EBV infection

in Primary Immunodeficiencies

Jiaxun Li
Dongcan Mo
Luyu Lv
Fuling Huang
Binyan Wu
Chunjuan He
Hao Wu
Wenpeng Pang
Yan Li
Liping Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1580909

382 views

Case Report

Accepted on 28 May 2025

Preserved umbilical cords underscore family histories of inborn errors of immunity

in Primary Immunodeficiencies

Madoka Nishimura
Dan Tomomasa
Rika Suzuki
Futaba Miyaoka
Hirokazu Kanegane

Frontiers in Immunology

doi 10.3389/fimmu.2025.1605857

151 views

Original Research

Published on 27 May 2025

Expansion of CD57+ CD8 T cells in common variable immunodeficiency with hepatopathy and CMV infection

in Primary Immunodeficiencies

Patrick Bez
Enrico Santangeli
Sigune Goldacker
Ulrich Salzer
Klaus Warnatz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1577934

434 views

Review

Accepted on 26 May 2025

X-Linked Lymphoproliferative Disease Type 1 (XLP1): A clinical and genetic update

in Primary Immunodeficiencies

Jiaxun Li
Luyu Lv
Qingqing Wei
Wenpeng Pang
Chunjuan He
Hao Wu
Liping Guo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620327

125 views

Case Report

Published on 26 May 2025

Case Report: Biliary hemorrhage by intrahepatic pseudoaneurysm and asymptomatic right coronary artery pseudoaneurysm in a patient with STAT3 hyper IgE syndrome

in Primary Immunodeficiencies

Daiki Fujita
Masahiro Ueki
Hiroshi Yamanaka
Kota Watanabe
Satoshi Yakuwa
Atsushi Manabe
Masafumi Yamada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1601776

333 views

Original Research

Accepted on 23 May 2025

Navigating disruption in the PID landscape: embracing opportunities and anticipating threats in the next ten years

in Primary Immunodeficiencies

Lúcia Mamede
Roser Cantenys Sabà
Samya Van Coillie
Johan Prevot
Silvia Sánchez-Ramón
Maria Cecilia Poli
Anne Barasa
Björn Wolfgang Schuller
Ayal Hendel
Nicolas Garcelon

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596971

166 views

Case Report

Published on 19 May 2025

Fatal HLH in patients with X-linked lymphoproliferative disease 1 due to a novel variant in SH2D1A: case report

in Primary Immunodeficiencies

Oksana Boyarchuk
Alla Volokha
Nataliia Yarema
Olga Dyvoniak
Tetyana Tomashivska
Ivanna Shymanska
Halyna Makukh
Jolan E. Walter

Frontiers in Immunology

doi 10.3389/fimmu.2025.1602107

996 views

Mini Review

Published on 19 May 2025

The clinical and socioeconomic aspects of t-cell receptor excision circle based newborn screening for severe combined immunodeficiency in Southeast and East Asia

in Primary Immunodeficiencies

Noelle Yoo
Seongjin Kim
Jane Kim
Jong Gyun Ahn
Insoo Kang
Junghee J. Shin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1549768

841 views

Original Research

Published on 15 May 2025

Granulomatous lymphocytic interstitial lung disease in common variable immune deficiency: an in-depth clinical, immunological, functional and radiological exploration with a focus on its management, challenged by chronic CMV infection

in Primary Immunodeficiencies

Mattia Moratti
Gioacchino Schifino
Francesco Baccelli
Simona Ferrari
Elisabetta Magrini
Mirna Bassi
Aldo Guerrieri
Maurizio Zompatori
Marcello Lanari
Francesca Conti

Frontiers in Immunology

doi 10.3389/fimmu.2025.1589052

1,069 views

Original Research

Published on 14 May 2025

Real-world evidence of the effectiveness and utilization of subcutaneous C1INH long-term prophylaxis in patients with HAE in Spain and Germany

in Primary Immunodeficiencies

Marcus Maurer
Stefan Cimbollek
Maebh Kelly
Kyle Rodney
John Elliott
Eduardo LoboGuerrero
Markus Magerl

Frontiers in Immunology

doi 10.3389/fimmu.2025.1576235

1,162 views

Original Research

Published on 09 May 2025

The effects of postponing BCG vaccination on the risk of BCG-related complications among patients with severe combined immunodeficiency disease in Saudi Arabia

in Primary Immunodeficiencies

Amal Aldhaheri
Ohoud Alyabes
Suliman Aljumaah
Raghad Alhuthil
Raghad Alonazi
Shefa Alamoudi
Mohammed Alsuhaibani
Salem Alghamdi
Esam A. Albanyan
Sami Al-Hajjar

Frontiers in Immunology

doi 10.3389/fimmu.2025.1596963

1,543 views

Case Report

Published on 08 May 2025

EBV-positive diffuse large B cell lymphoma secondary to activated phosphoinositide 3 kinase δ syndrome type 1 (APDS1): a case report and literature review

in Primary Immunodeficiencies

Qiu-yuan Xiang
Min Zuo
Ji-Hao Zhou
Chun Feng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1583405

846 views