Ameloblastoma is an epithelial tumor of odontogenic origin that occurs in the jaws of dogs and other species, including humans. Canine ameloblastoma is of major veterinary relevance due to its relatively high prevalence and its locally invasive behavior; there is also major interest in refining traditional treatment modalities because they are associated with significant patient morbidity. Additionally, client-owned dogs with naturally occurring disease are of interest as comparative and potentially useful translational models of human disease based on the remarkable similarities of canine and human ameloblastoma.
Most of what is currently known about ameloblastomas in dogs has been reported during the course of the last three decades. Although such rapidly evolving knowledge has greatly improved the quality of patient care, it has also generated some degree of confusion due to changes in nomenclature, diagnostic criteria and therapeutic approaches. More recently, tissue engineering surgical solutions have been proposed and breakthrough molecular discoveries have been made, both of which have the potential to redefine current standards of care.
The goal of this Retrospective Research Topic is to provide readers an update on the most recent advances in ameloblastoma research in dogs in the context of current and future veterinary clinical applications and “One Health”; Review and Opinion articles that are making an impact on this field of veterinary medicine will be considered, covering themes including but not limited to:
- Molecular pathogenesis of ameloblastoma in the context of personalized medicine solutions and “One Health”
- Surgical margins and outcome of excision of ameloblastoma
- Regenerative approach to reconstruction following excision of ameloblastoma
- Diagnostic imaging aspects of ameloblastoma
- Comparative aspects of ameloblastoma
Ameloblastoma is an epithelial tumor of odontogenic origin that occurs in the jaws of dogs and other species, including humans. Canine ameloblastoma is of major veterinary relevance due to its relatively high prevalence and its locally invasive behavior; there is also major interest in refining traditional treatment modalities because they are associated with significant patient morbidity. Additionally, client-owned dogs with naturally occurring disease are of interest as comparative and potentially useful translational models of human disease based on the remarkable similarities of canine and human ameloblastoma.
Most of what is currently known about ameloblastomas in dogs has been reported during the course of the last three decades. Although such rapidly evolving knowledge has greatly improved the quality of patient care, it has also generated some degree of confusion due to changes in nomenclature, diagnostic criteria and therapeutic approaches. More recently, tissue engineering surgical solutions have been proposed and breakthrough molecular discoveries have been made, both of which have the potential to redefine current standards of care.
The goal of this Retrospective Research Topic is to provide readers an update on the most recent advances in ameloblastoma research in dogs in the context of current and future veterinary clinical applications and “One Health”; Review and Opinion articles that are making an impact on this field of veterinary medicine will be considered, covering themes including but not limited to:
- Molecular pathogenesis of ameloblastoma in the context of personalized medicine solutions and “One Health”
- Surgical margins and outcome of excision of ameloblastoma
- Regenerative approach to reconstruction following excision of ameloblastoma
- Diagnostic imaging aspects of ameloblastoma
- Comparative aspects of ameloblastoma
