Research Topic

New Emerging Functions of Transcription Factors in the Development of Hematological Malignancies

About this Research Topic

Transcription factors regulate the differentiation of hematopoietic cells. It has been shown for a number of transcription factors that deregulated expression or structural variants can contribute to the development of hematological malignancies by inducing epigenetic changes. Besides these classical functions, recent year research has implicated transcription factors in metabolic alteration, DNA repair, 3D genome structure changes or even implication of transcription factors in immune cell and stroma function. Finally, with the rise of new classes of drugs, it has become possible to target transcription factors. The aim of this Research Topic is to review the latest development in this field and present primary research on how to advance the field.

The goal is to spot new light on the function of transcription factors in the development of hematological malignancies. It shall give all readers an overview over the latest development and which new frontiers need to be addressed in the future.

We are especially interested in:
-Novel function of transcription factor in the development of hematological malignancies
-How this can exploited possibly on a therapeutic level
-Overview of the function of transcription factor in the development of leukemia and lymphoma

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.


Keywords: Transcription factor, Leukemia, Lymphoma, Epigenetic, 3D structure, Stroma


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Transcription factors regulate the differentiation of hematopoietic cells. It has been shown for a number of transcription factors that deregulated expression or structural variants can contribute to the development of hematological malignancies by inducing epigenetic changes. Besides these classical functions, recent year research has implicated transcription factors in metabolic alteration, DNA repair, 3D genome structure changes or even implication of transcription factors in immune cell and stroma function. Finally, with the rise of new classes of drugs, it has become possible to target transcription factors. The aim of this Research Topic is to review the latest development in this field and present primary research on how to advance the field.

The goal is to spot new light on the function of transcription factors in the development of hematological malignancies. It shall give all readers an overview over the latest development and which new frontiers need to be addressed in the future.

We are especially interested in:
-Novel function of transcription factor in the development of hematological malignancies
-How this can exploited possibly on a therapeutic level
-Overview of the function of transcription factor in the development of leukemia and lymphoma

Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.


Keywords: Transcription factor, Leukemia, Lymphoma, Epigenetic, 3D structure, Stroma


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

27 November 2021 Abstract
26 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

27 November 2021 Abstract
26 January 2022 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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