Neurodegenerative diseases are a class of chronic and irreversible disorders characterized by progressive degeneration and loss of function of the central and/or peripheral nervous systems. The main pathological feature of neurodegenerative disease in the central nervous system (CNS) is the selective neuronal loss in the brain and spinal cord, leading to cognitive and/or motor dysfunction. The immune system plays a variety of roles in the pathophysiology of neurodegenerative diseases. Current understanding of microglia from basic and clinical findings is as the main innate immune cells in the brain, which can be activated and involved in the neuroinflammation in nearly all the neurodegenerative disorders. In recent years, many scientists have shifted their ground on conceptualizing neurodegenerative disease as a neuron-centric disease; rather, a close functional connection between the peripheral immune system and central nervous system has been increasingly acknowledged. An increasing number of circulating immune cells have been detected in the neurodegenerative brains. For example, studies showed that peripheral innate immune cells, also known as bone marrow-derived microglia, can directly infiltrate into the brain and possibly limit disease progression in Alzheimer’s Disease. In this regard, understanding how the peripheral immune system interacts with the central nervous system in terms of regulating the onset and development of neurodegenerative diseases assume importance. Studies aim at exploring the role of the peripheral immune system in neurodegenerative diseases will help to identify new targets and improve the feasibility of therapeutic interventions.
For this Research Topic, we welcome submissions of Original Research, Brief Research Reports, Reviews, Mini-Reviews, and Opinions on the peripheral immune system and any kind of neurodegenerative disorder, including Alzheimer’s disease, Parkinson's disease, or Amyotrophic Lateral Sclerosis, Multiple system atrophy, et al. and other neurodegenerative pathological changes under certain conditions on the following themes:
- Relationship between the peripheral innate immune and neurodegenerative disease or neurodegenerative pathological changes
- Studies on the peripheral adapt immune and neurodegenerative disease or neurodegenerative pathological changes
- Immunology related serum or plasma or blood platelet studies on neurodegenerative disease or neurodegenerative pathological changes
- Relationship between immune-related diseases and neurodegenerative diseases
- The crosstalk between the peripheral and immunity and central nervous system
Neurodegenerative diseases are a class of chronic and irreversible disorders characterized by progressive degeneration and loss of function of the central and/or peripheral nervous systems. The main pathological feature of neurodegenerative disease in the central nervous system (CNS) is the selective neuronal loss in the brain and spinal cord, leading to cognitive and/or motor dysfunction. The immune system plays a variety of roles in the pathophysiology of neurodegenerative diseases. Current understanding of microglia from basic and clinical findings is as the main innate immune cells in the brain, which can be activated and involved in the neuroinflammation in nearly all the neurodegenerative disorders. In recent years, many scientists have shifted their ground on conceptualizing neurodegenerative disease as a neuron-centric disease; rather, a close functional connection between the peripheral immune system and central nervous system has been increasingly acknowledged. An increasing number of circulating immune cells have been detected in the neurodegenerative brains. For example, studies showed that peripheral innate immune cells, also known as bone marrow-derived microglia, can directly infiltrate into the brain and possibly limit disease progression in Alzheimer’s Disease. In this regard, understanding how the peripheral immune system interacts with the central nervous system in terms of regulating the onset and development of neurodegenerative diseases assume importance. Studies aim at exploring the role of the peripheral immune system in neurodegenerative diseases will help to identify new targets and improve the feasibility of therapeutic interventions.
For this Research Topic, we welcome submissions of Original Research, Brief Research Reports, Reviews, Mini-Reviews, and Opinions on the peripheral immune system and any kind of neurodegenerative disorder, including Alzheimer’s disease, Parkinson's disease, or Amyotrophic Lateral Sclerosis, Multiple system atrophy, et al. and other neurodegenerative pathological changes under certain conditions on the following themes:
- Relationship between the peripheral innate immune and neurodegenerative disease or neurodegenerative pathological changes
- Studies on the peripheral adapt immune and neurodegenerative disease or neurodegenerative pathological changes
- Immunology related serum or plasma or blood platelet studies on neurodegenerative disease or neurodegenerative pathological changes
- Relationship between immune-related diseases and neurodegenerative diseases
- The crosstalk between the peripheral and immunity and central nervous system