About this Research Topic
One issue that should be addressed in high-risk non-muscle-invasive bladder cancer studies is to obtain new efficacy drugs by high quality and precision patient-oriented studies. Consequently, well-designed single-arm phase 2–3 trials to compare novel therapies to pre-specified study endpoints and stratification of patients according to their molecular profile should be the standard for evolution of treatments for this disease.
Here we will present the most recent studies and evidence for bladder sparing treatment of patients with high-risk NMIBC. We will investigate the role of molecular markers in optimizing the adequate selection of patients for studies in order to not consume resources.
Topics of interest includes:
-The current status of art of the treatment for HR NMIBC
-Understanding BCG failure classification
-The current status of art of molecular biomarkers
-Immunologic landscape of microenvironment of NMIBC
-Therapies in pipeline (phase II/III) for HG-NMIBC
-New frontiers in urinary microbiota in NMIBC
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: bladder cancer, therapy, BCG, new drugs, molecular biomarkers, high-risk NMIBC
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