About this Research Topic
Tissue regeneration is a vital process maintaining the survival and functions of different biological organs and systems. The regenerative process usually consists of three stages involving the body's response following the tissue damage due to trauma, pathological mechanisms, autoimmunity or chemicals/toxins. These regenerative phases include inflammation, repair, and remodelling. Multipotent stromal cells are known to play a role in all three stages of tissue regeneration. These stromal cells have multiple and unique functions compared to other eukaryotic cells. Multipotent stromal cells can differentiate into specific cells belonging to bone, cartilage, fat, skin, tendon, brain, and other tissues. Additionally, these stromal cells can interact with various immune cells, thus modulating the innate and adaptive immune response. Besides differentiation and immunomodulation, multipotent stromal cells have other support functions for endothelial cells and help angiogenesis.
The therapeutic potential of multipotential stem cells is highly considered, and extensive research is ongoing for their use in several degenerative conditions and diseases. Some crucial components that supplement the regenerative capability of multipotent stromal cells include materials that provide 3D support for cell survival and functions, as well as growth factors as supplementary factor for multipotent stromal cell-based therapies. It is essential to understand how native or transplanted stromal cells can interact with the components of the healing microenvironment. Such knowledge will enrich the understanding of the tissue regeneration process. Furthermore, research into the crosstalk between stromal cells and healing microenvironment components would have excellent value for identifying cellular, molecular, and biomaterial candidates that can promote stromal cell-based therapies.
This research topic welcomes manuscripts discussing these interesting topics:
* Interactions between stromal cells and immune cells or mediators as well as interactions between stromal cells and their surrounding matrix.
* Interactions between multipotent stromal cells and damage-related mediators and other components of healing niches.
* The research involving biomaterials and devices that help study or support the effect of the cellular therapies and different cellular and molecular interactions.
* Research on clinical translation of stromal cell therapies for degenerative conditions and diseases.
Both research articles and review articles are welcomed.
The therapeutic potential of multipotential stem cells is highly considered, and extensive research is ongoing for their use in several degenerative conditions and diseases. Some crucial components that supplement the regenerative capability of multipotent stromal cells include materials that provide 3D support for cell survival and functions, as well as growth factors as supplementary factor for multipotent stromal cell-based therapies. It is essential to understand how native or transplanted stromal cells can interact with the components of the healing microenvironment. Such knowledge will enrich the understanding of the tissue regeneration process. Furthermore, research into the crosstalk between stromal cells and healing microenvironment components would have excellent value for identifying cellular, molecular, and biomaterial candidates that can promote stromal cell-based therapies.
This research topic welcomes manuscripts discussing these interesting topics:
* Interactions between stromal cells and immune cells or mediators as well as interactions between stromal cells and their surrounding matrix.
* Interactions between multipotent stromal cells and damage-related mediators and other components of healing niches.
* The research involving biomaterials and devices that help study or support the effect of the cellular therapies and different cellular and molecular interactions.
* Research on clinical translation of stromal cell therapies for degenerative conditions and diseases.
Both research articles and review articles are welcomed.
Keywords: Multipotent stromal cells, Healing Regeneration, Immune response, Damage-related proteins, Biomaterials, Growth factors
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
