Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) and Sjogren’s Syndrome (SS) are typical autoimmune diseases (AID). Genetic susceptibility and environmental triggers are generally known as the major etiology for AID. Both have deep impact on the host metabolism. Advancement in sequencing and omics techniques sheds light on gut microbiome and host metabolism in the immunopathogenesis in AID. Their role in AID development and drug efficacy has been implied via metagenomics, immunometabolism and pharmacomicrobiomics studies, which opens a new avenue for deeper understanding and better control of AID. Therefore, the exploration of the link between gut microbiota, metabolism and autoimmunity is ardently expected. Specifically, the association of glycometabolism, lipid metabolism, amino acid metabolism, iron metabolism and gut microbial metabolites with host autoimmune response in SLE, RA and SS is of keen interest.
This research topic is aimed to provide a forum to advance research on revealing the contribution of gut microbiota and immunometabolism to the initiation of autoimmunity and the development of autoimmune diseases, and also to fuel further in-depth studies of innovative interventions via gut microbiota modification or metabolism regulations. We welcome Original Research Articles and Review Articles in, but not limited to the following sub-topics:
• Role of gut microbiota in regulating host immunometabolism
• Mechanisms of gut microbiota and their metabolites contributing to typical rheumatic diseases
• Glucometabolic alterations in AID
• Association of aberrant glycolysis with malfunction of innate immune cells
• Role of glucometabolic change in adaptive immune cell activation
• Lipid metabolism dysregulation in AID
• Oxidative stress in initiation and expansion of autoimmunity
• Iron metabolism and its contribution to immune response and autoimmunity
• Amino acid metabolism in AID
• Cross-reaction of gene, diet, drug, and gut microbiota in AID (SLE/SS/RA)
• Novel gut microbiome-oriented prophylactic and therapeutic strategies in AID (SLE/SS/RA) control
• Prospect of immunometabolism intervention in AID control (SLE/SS/RA)
Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA) and Sjogren’s Syndrome (SS) are typical autoimmune diseases (AID). Genetic susceptibility and environmental triggers are generally known as the major etiology for AID. Both have deep impact on the host metabolism. Advancement in sequencing and omics techniques sheds light on gut microbiome and host metabolism in the immunopathogenesis in AID. Their role in AID development and drug efficacy has been implied via metagenomics, immunometabolism and pharmacomicrobiomics studies, which opens a new avenue for deeper understanding and better control of AID. Therefore, the exploration of the link between gut microbiota, metabolism and autoimmunity is ardently expected. Specifically, the association of glycometabolism, lipid metabolism, amino acid metabolism, iron metabolism and gut microbial metabolites with host autoimmune response in SLE, RA and SS is of keen interest.
This research topic is aimed to provide a forum to advance research on revealing the contribution of gut microbiota and immunometabolism to the initiation of autoimmunity and the development of autoimmune diseases, and also to fuel further in-depth studies of innovative interventions via gut microbiota modification or metabolism regulations. We welcome Original Research Articles and Review Articles in, but not limited to the following sub-topics:
• Role of gut microbiota in regulating host immunometabolism
• Mechanisms of gut microbiota and their metabolites contributing to typical rheumatic diseases
• Glucometabolic alterations in AID
• Association of aberrant glycolysis with malfunction of innate immune cells
• Role of glucometabolic change in adaptive immune cell activation
• Lipid metabolism dysregulation in AID
• Oxidative stress in initiation and expansion of autoimmunity
• Iron metabolism and its contribution to immune response and autoimmunity
• Amino acid metabolism in AID
• Cross-reaction of gene, diet, drug, and gut microbiota in AID (SLE/SS/RA)
• Novel gut microbiome-oriented prophylactic and therapeutic strategies in AID (SLE/SS/RA) control
• Prospect of immunometabolism intervention in AID control (SLE/SS/RA)