Glycemic dysregulation is linked with numerous diseases. These include but are not limited to cardiovascular diseases, metabolic diseases, and cancers. Blood glucose is typically controlled within a narrow range through the integration of multiple organ systems and tissues. Skeletal muscle is the bulk of insulin sensitive tissue and thereby plays a major role in glucoregulation. Much of the work uncovering the role of skeletal muscle in regulating glucose metabolism has focused on muscle parenchymal cells – myocytes or myofibers. Paralleling recent advancements in ‘omics’ technologies, burgeoning research supports that non-parenchymal cell types in skeletal muscle (i.e., extramyocellular cells) are important in regulating tissue function and participate in coordinating muscle glucose metabolism. Uncovering the mechanisms of crosstalk between non-parenchymal cells and muscle cells in modulating muscle glucose metabolism will lead to opportunities for the development of novel therapeutics in health, disease, and over the lifespan.
The aim of the current Research Topic is to cover promising, recent, and novel research directions in the crosstalk between heterogeneous cell types in skeletal muscle and how these interactions regulate muscle glucose uptake and metabolism.
Areas to be covered in this Research Topic may include, but are not limited to:
- Autocrine/paracrine actions of extramyocellular cells within skeletal muscle tissue on myocytes in normal physiological states (fasting, feeding, exercise, environmental temperature), aging, and disease states
- Sex/gender differences
- Circadian biology
- Novel experimental tools or approaches to phenotype extramyocellular cells
Glycemic dysregulation is linked with numerous diseases. These include but are not limited to cardiovascular diseases, metabolic diseases, and cancers. Blood glucose is typically controlled within a narrow range through the integration of multiple organ systems and tissues. Skeletal muscle is the bulk of insulin sensitive tissue and thereby plays a major role in glucoregulation. Much of the work uncovering the role of skeletal muscle in regulating glucose metabolism has focused on muscle parenchymal cells – myocytes or myofibers. Paralleling recent advancements in ‘omics’ technologies, burgeoning research supports that non-parenchymal cell types in skeletal muscle (i.e., extramyocellular cells) are important in regulating tissue function and participate in coordinating muscle glucose metabolism. Uncovering the mechanisms of crosstalk between non-parenchymal cells and muscle cells in modulating muscle glucose metabolism will lead to opportunities for the development of novel therapeutics in health, disease, and over the lifespan.
The aim of the current Research Topic is to cover promising, recent, and novel research directions in the crosstalk between heterogeneous cell types in skeletal muscle and how these interactions regulate muscle glucose uptake and metabolism.
Areas to be covered in this Research Topic may include, but are not limited to:
- Autocrine/paracrine actions of extramyocellular cells within skeletal muscle tissue on myocytes in normal physiological states (fasting, feeding, exercise, environmental temperature), aging, and disease states
- Sex/gender differences
- Circadian biology
- Novel experimental tools or approaches to phenotype extramyocellular cells
