About this Research Topic
The ability of a protein to moonlight in different multi-protein complexes or pathways can complicate the prediction of protein function from sequence or structure and the annotation of sequence databases. To date, most moonlighting functions have been found by serendipity. There is currently no straightforward method to identify which proteins moonlight, or for determining if a protein of interest is a moonlighting protein. In addition, sequence homologues of moonlighting proteins often do not perform both functions.
This research topic will include publications on many aspects of moonlighting proteins - examples of proteins that moonlight, structures of moonlighting proteins, their roles in diseases, how they may have evolved, moonlighting proteins and proteomics, bioinformatics of moonlighting proteins, etc.
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