Research Topic

Human Thyroid Cancers: Oncogenes, Tumor Suppressors, Regulation of Tumor Microenvironment, and Preclinical Animal Models

About this Research Topic

This Research Topic is devoted to the understanding of molecular mechanisms of Human Thyroid Cancers.
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This Research Topic is devoted to the understanding of molecular mechanisms of Human Thyroid Cancers.

This Research Topic will welcome original research describing novel functional studies of genetic mutations that shed novel insights into the aetiology and pathogenesis of these cancers, as well as genome-wide and proteomic analysis studies, angiogenesis and cancer studies, tumor microenvironment, mouse models studies that describe mechanisms or novel potential therapies for these cancers, and cohort studies revealing novel genetic associations and identification of functional polymorphisms that occur in these endocrine cancers. Finally, studies based on descriptions of novel laboratory techniques or innovative protocols applied to the study of these endocrine cancers will also be welcomed.

Scopes:
The scope of this Research Topic is to cover the entire field of thyroid cancers: the main focus of this Topic will also be translational with emphasis on bench to bedside research.

This Topic will have a particular interest in experimental, pre-clinical and clinical research addressing the following issues:
1) Identification of specific molecular patterns of thyroid tumorigenesis, which could allow the development of new directions in the field of pharmacotherapy research;
2) Emphasis on animal studies (preclinical models of human thyroid cancers) of new drugs and molecule-targeted agents with the potential to lead to clinical trials, and studies of targetable mechanisms of oncogenesis, progression of these malignancies, tumor microenvironment and extracellular matrix, and metastatic disease;
3) Discovery of new biomarkers to predict response or resistance to drug treatment (targeted cancer therapies) or to guide the follow-up of treated patients;
4) Identification of new laboratory molecular tests (e.g. molecular techniques and applications of thyroid fine-needle aspiration biopsy) and molecular bioimaging techniques to translate in the clinical diagnosis;

In summary, specific areas of interest include:
cancer genetics; genome-wide analysis; clinical and translational research in targeted therapies; mechanisms of drug sensitivity and resistance; mouse models; pharmacogenetics and pharmacogenomics; personalized medicine; novel applications of bioinformatics; large scale molecular characterization of tumors; diagnostic or prognostic biomarkers; endocrine pathology studies; innovative molecular in vivo and ex-vivo bioimaging with potential applicability to clinical investigation.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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