Cell-based biosensing technologies are rapidly developed over decades to promote advances in the biomedical field. Cell-based biosensing technologies take the cell as the primary sensing element and utilize physical or chemical sensors as the secondary transducers. Cells can sensitively sense the weak or trace changes in the extracellular microenvironment, leading to the fluctuations of electrophysiology, metabolism, or viability. These cellular fluctuations can be effectively converted into electrical or optical signals. To detect the weak signals or trace biomarkers of cells, high-sensitive and high-accurate cell-based biosensing technologies are in urgent demand in theoretical investigation and practical application. The advances in the theoretical investigation and practical application provide the feedback to effectively improve the cell-based biosensing device and technology. The advanced cell-based biosensing technologies pave new avenues to achieve disease investigation, environmental monitoring, pharmaceutical screening.
The cell-based biosensor, technology, and system should be not only improved by the theoretical investigation but also designed based on practical application. Model-modal cell-based bioelectronics/biophotonics technologies can monitor the electrophysiology, metabolism, viability in a sensitive manner. Using electrical or optical sensors/probes, the intracellular/extracellular electrophysiological and metabolism could be sensitively detected in a minimally invasive way. Both 3D and planar cellular models could be successfully established and continuously monitored. Moreover, physical or chemical triggering regulation could be applied to cell-based models to promote a deep understanding of the mechanism of cell biology. Combing the nano/microtechnologies, the cell behavior or physiology can be investigated from the three-dimensional organ in vivo level to single cultured cell in vitro level, and from the extracellular level to intracellular level. Multi-modal cell-based biosensing technologies further reveal the high-content information of cell physiology or pharmaceutical functions, which might replace conventional cell-based biosensing technologies in the near future.
This research topic aims to publish Original Research, Review, Case report, Empirical study, and Opinion on topics including, but not limited to:
• Cell-based Biosensors
• Micro/nanostructure for biosensing application
• Intracellular and extracellular electrophysiological detection
• Intracellular and extracellular metabolism detection
• 3D and planar cellular viability detection
• Cellular biomechanic sensors
• Microfluidic devices for cell analysis
• Cell-based optical biosensors
• Synthetic biological probes/sensors towards cell analysis
• Supramolecular chemical probes/sensors towards cell analysis
• Multifunctional cell-based bioelectronic system
• Multi-modal cell-based biophotonic system
• Organoid/3D cell model-on-a-chip
• Single cell analysis/sequencing
Cell-based biosensing technologies are rapidly developed over decades to promote advances in the biomedical field. Cell-based biosensing technologies take the cell as the primary sensing element and utilize physical or chemical sensors as the secondary transducers. Cells can sensitively sense the weak or trace changes in the extracellular microenvironment, leading to the fluctuations of electrophysiology, metabolism, or viability. These cellular fluctuations can be effectively converted into electrical or optical signals. To detect the weak signals or trace biomarkers of cells, high-sensitive and high-accurate cell-based biosensing technologies are in urgent demand in theoretical investigation and practical application. The advances in the theoretical investigation and practical application provide the feedback to effectively improve the cell-based biosensing device and technology. The advanced cell-based biosensing technologies pave new avenues to achieve disease investigation, environmental monitoring, pharmaceutical screening.
The cell-based biosensor, technology, and system should be not only improved by the theoretical investigation but also designed based on practical application. Model-modal cell-based bioelectronics/biophotonics technologies can monitor the electrophysiology, metabolism, viability in a sensitive manner. Using electrical or optical sensors/probes, the intracellular/extracellular electrophysiological and metabolism could be sensitively detected in a minimally invasive way. Both 3D and planar cellular models could be successfully established and continuously monitored. Moreover, physical or chemical triggering regulation could be applied to cell-based models to promote a deep understanding of the mechanism of cell biology. Combing the nano/microtechnologies, the cell behavior or physiology can be investigated from the three-dimensional organ in vivo level to single cultured cell in vitro level, and from the extracellular level to intracellular level. Multi-modal cell-based biosensing technologies further reveal the high-content information of cell physiology or pharmaceutical functions, which might replace conventional cell-based biosensing technologies in the near future.
This research topic aims to publish Original Research, Review, Case report, Empirical study, and Opinion on topics including, but not limited to:
• Cell-based Biosensors
• Micro/nanostructure for biosensing application
• Intracellular and extracellular electrophysiological detection
• Intracellular and extracellular metabolism detection
• 3D and planar cellular viability detection
• Cellular biomechanic sensors
• Microfluidic devices for cell analysis
• Cell-based optical biosensors
• Synthetic biological probes/sensors towards cell analysis
• Supramolecular chemical probes/sensors towards cell analysis
• Multifunctional cell-based bioelectronic system
• Multi-modal cell-based biophotonic system
• Organoid/3D cell model-on-a-chip
• Single cell analysis/sequencing
