Inflammatory state and insulin resistance are present in several chronic diseases, for example obesity, type 2 diabetes mellitus, cardiovascular diseases, and metabolic syndrome. Several studies have demonstrated a clear association among nutrients, dietary bioactive compounds, inflammatory markers, and insulin sensitivity, although the molecular and cellular mechanisms are not fully understood yet.
The present Research Topic aims to join efforts for the comprehension of the effects of different nutrients, dietary bioactive compounds, and/or supplements on inflammation and/or insulin resistance in different experimental models (cells, animals, and humans), in healthy and pathological conditions. In particular, we are interested in cellular and molecular mechanisms involved in these processes, including pro- and anti-inflammatory pathways, insulin signaling modulation, oxidative stress regulation, mitochondrial function alteration, and gene expression control, in different cell types (adipocytes, myotubes, hepatocytes, cardiac cells, immune cells, among others). Identification of molecular targets, crosstalk between inflammation and insulin resistance, and potential nutritional interventions are also welcome.
The following general topics will be covered for this Research Topic:
1) Role of the nutrition on the pathogenesis of inflammatory and metabolic diseases;
2) Modulation of inflammation and insulin resistance by different nutrients, dietary active compounds, and supplements;
3) Nutritional modulation of inflammatory and insulin signaling pathways in different cell types;
4) Identification of potential molecular and cellular targets for prevention and/or treatment of inflammatory and metabolic diseases;
5) Nutritional modulation of gene expression associated with inflammation and insulin resistance;
6) Function of the nutrition in the crosstalk between inflammation and insulin resistance.
Inflammatory state and insulin resistance are present in several chronic diseases, for example obesity, type 2 diabetes mellitus, cardiovascular diseases, and metabolic syndrome. Several studies have demonstrated a clear association among nutrients, dietary bioactive compounds, inflammatory markers, and insulin sensitivity, although the molecular and cellular mechanisms are not fully understood yet.
The present Research Topic aims to join efforts for the comprehension of the effects of different nutrients, dietary bioactive compounds, and/or supplements on inflammation and/or insulin resistance in different experimental models (cells, animals, and humans), in healthy and pathological conditions. In particular, we are interested in cellular and molecular mechanisms involved in these processes, including pro- and anti-inflammatory pathways, insulin signaling modulation, oxidative stress regulation, mitochondrial function alteration, and gene expression control, in different cell types (adipocytes, myotubes, hepatocytes, cardiac cells, immune cells, among others). Identification of molecular targets, crosstalk between inflammation and insulin resistance, and potential nutritional interventions are also welcome.
The following general topics will be covered for this Research Topic:
1) Role of the nutrition on the pathogenesis of inflammatory and metabolic diseases;
2) Modulation of inflammation and insulin resistance by different nutrients, dietary active compounds, and supplements;
3) Nutritional modulation of inflammatory and insulin signaling pathways in different cell types;
4) Identification of potential molecular and cellular targets for prevention and/or treatment of inflammatory and metabolic diseases;
5) Nutritional modulation of gene expression associated with inflammation and insulin resistance;
6) Function of the nutrition in the crosstalk between inflammation and insulin resistance.
