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Oxytocin: control of bone and fat mass and metabolism

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Osteoporosis and overweight/obesity constitute major worldwide public health burdens. Human life expectancy has increased continuously in industrialized countries. Aging is associated with immunosenescence, a decrease in hormonal secretion, lean mass and bone mass, and an increase in fat accumulation. It has ...

Osteoporosis and overweight/obesity constitute major worldwide public health burdens. Human life expectancy has increased continuously in industrialized countries. Aging is associated with immunosenescence, a decrease in hormonal secretion, lean mass and bone mass, and an increase in fat accumulation. It has been reported that both obesity and osteoporosis are affected by genetic and environmental factors, bone remodeling and adiposity are both regulated through the hypothalamus and sympathetic nervous system; mesenchymal stem cell represent a common precursor for adipocytes and osteoblasts and that adipose tissue and skeleton are endocrine organs. Oxytocin, belongs to the pituitary hormone family and regulates the function of peripheral target organs. It also modulates a wide range of behaviors, such as social recognition, love, and fear. The levels of oxytocin decreased with age. The crosstalk between bone and energy metabolism has been clearly evidenced in the last years through the investigations on the role of leptin, osteocalcin and other molecules. Several reports, published recently, show clearly that oxytocin could play an important role in the control of bone and fat mass and their metabolism.


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