About this Research Topic
In addition to chemo- and radiotherapeutic approaches, cancer immunotherapies, including chimeric antigen receptor T-cell (CAR-T cells), have emerged as an effective therapeutic tool by directing immunocompetent cells against the cancer target. Besides, recent advances in the treatment of various types of cancer include CRISPR/Cas9 gene editing, theranostics, virus-mediated therapy, etc. Several stem cell types, including hematopoietic stem cells derived from umbilical cord blood, bone marrow, or mobilized peripheral blood, as well as CAR-T cells, have been used for cancer treatment and/or have been engineered to deliver tumor-targeted therapeutic drugs (biological vehicle). Even induced pluripotent stem cells (iPSCs) have been differentiated to active T-cells to reinforce cancer immunotherapy. MSCs-derived exosomes of note have been described as exhibiting tumor-suppressing effects. Certainly, MSCs remain a promising source of stem cells and an interesting therapeutic alternative to target cancer. Although MSC-based therapy has been identified as a cellular tool with the potential to treat cancer, the therapeutic use of MSCs for cancer has been challenged by contradictory pre-clinical studies suggesting both anti- and protumor effects. Despite this controversy, recent MSC-based therapies are providing highly effective and promising anticancer treatments. There is definitely a great scientific and clinical interest in generating a safe and effective MSC-based treatment for cancer to help improve the survival and quality of life (QoL) of patients suffering from this devastating disease.
Altogether, this Research Topic aims to highlight the recent advances, to cover the progress of basic and preclinical research, to address the relevant and novel therapeutic strategies, to identify and discuss the pitfalls, limiting factors and critical aspects to be considered for cancer-fighting benefits of the MSCs applications. Consequently, to elucidate the mechanism of action (MoA) of MSCs and to better understand the interaction between MSCs and cancer cells and thus further improve the clinical feasibility, safety and efficacy of MSCs cell-based therapeutic approaches.
This Research Topic is seeking to collect the latest finding and achievements in the field of MSCs cell-based therapy for cancer. We welcome submissions of original research, systematic review, mini-review, hypothesis and theory, opinion, method, brief research report, letters to the editor, commentary, and opinions.
The topic is broad and intends to cover research-related but not limited to:
• MSCs cell-based therapy in cancer
• Immunomodulation and cancer immunotherapies
• Molecular and cellular processes underlying therapeutic effects of MSCs in cancer
• MSCs, Epithelial-to-Mesenchymal Transition (EMT) and mesenchymal-to-epithelial transition (MET) in cancer
• Supportive and suppressive impacts of MSCs on tumor progression and metastasis (angiogenesis and tumor progression, homing to tumor sites)
• CRISPR/Cas9-based technology editing of MSCs in cancer immunotherapy
• MSCs-derived exosomes as mediators of immunomodulation and tissue repair
• MSCs, MSCs-derived exosomes and extracellular vesicles (EV) as biological carriers/vehicles for drug delivery.
Keywords: Mesenchymal stromal cells, cancer, cell therapy, T-cells, CAR T-cells, CRISPR/Cas9, exosomes, immunomodulation, cancer immunotherapies, chemotherapy, radiotherapy, theranostics, homing, anti-tumor, pro-tumor, drug delivery
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