Innate immune cells, such as members of the mononuclear phagocyte (MNP, ie Dendritic cells, Macrophages and Monocytes) family are known to sense a plethora of antigens and diverse molecular cues of potential pathology (the danger signals) of both self and non-self origins. This sensing is enriched by simultaneous and/or consecutive interactions with members of the adaptive immune system as well as cells from non-immune compartments. In addition, polymorphonuclear cells (PMNs, like neutrophils, eosinophils, basophils), mast cells, natural killer cells as well as the innate lymphoid cells (ILCs) also play a role in the shaping of the immune response in varied patho-physiological contexts. These complex interactions, with the innate immune cells being the key decision-makers, shape how eventually both cellular and humoral arms of the immune system are manifested. Different subset(s) of innate immune cells, depending on the microenvironments they experience and the functional capabilities they acquire, including dynamic metabolic characteristics, can differentially shape the outcome of immune responses. Thus, a detailed understanding on how the immune cells with innate immune functions contribute to regulation of adaptive immune responses is critical for deeper understanding of immunopathologies as well as for designing novel diagnostic and therapeutic tools.
Present the problem that you would like to tackle in this Research topic and what can be done to achieve it including recent advances.
This Research Topic aims to address how much of this basic knowledge on innate immune cells is useful to predict and solve human ailments with underlying immunopathologies. Evidence of the interaction between the innate and adaptive immune cells can be borne out of in vitro, in vivo and ex vivo experiments using preclinical models as well as human primary immune cells, be it in natural as well as in vaccine related immune responses against infectious diseases or cancer. Observations derived from human data in ‘steady state’ as well as from patients undergoing therapy and from humanized immune system mice can greatly improve our knowledge. Recent advancements in investigations focused on human immunopathologies as well as in instances where the immune system impedes delivery and action of biological therapeutics, provide opportunities to validate and extend the relevance of the role of innate immune cells in mechanistically controlling adaptive immune responses. Further, it is also important to understand the role of innate immune cells in the development of autoimmune and autoinflammatory responses as well as in cases of immunogenicity against protein, gene and cell therapeutics.
This Research Topic welcomes the submission of manuscripts focusing on, but not limited to, the following sub-topics:
• Human innate immune cells in different tissues: phenotype, development and function in physiopathology
• Activation and regulation of T cells and B cells by innate immune cells (MNPs, PMNs, NK cells and ILCs) resulting in human immunopathologies
• Tolerance inducing pathways in human antigen presenting cells and modulation of adaptive immune responses
• Murine models with Humanized Immune system – tools to study innate adaptive immune cross-talks in humans
• Immunogenicity of protein, gene and cell therapeutics: role of innate immune cells in human and non-human in vivo and in vitro models
Innate immune cells, such as members of the mononuclear phagocyte (MNP, ie Dendritic cells, Macrophages and Monocytes) family are known to sense a plethora of antigens and diverse molecular cues of potential pathology (the danger signals) of both self and non-self origins. This sensing is enriched by simultaneous and/or consecutive interactions with members of the adaptive immune system as well as cells from non-immune compartments. In addition, polymorphonuclear cells (PMNs, like neutrophils, eosinophils, basophils), mast cells, natural killer cells as well as the innate lymphoid cells (ILCs) also play a role in the shaping of the immune response in varied patho-physiological contexts. These complex interactions, with the innate immune cells being the key decision-makers, shape how eventually both cellular and humoral arms of the immune system are manifested. Different subset(s) of innate immune cells, depending on the microenvironments they experience and the functional capabilities they acquire, including dynamic metabolic characteristics, can differentially shape the outcome of immune responses. Thus, a detailed understanding on how the immune cells with innate immune functions contribute to regulation of adaptive immune responses is critical for deeper understanding of immunopathologies as well as for designing novel diagnostic and therapeutic tools.
Present the problem that you would like to tackle in this Research topic and what can be done to achieve it including recent advances.
This Research Topic aims to address how much of this basic knowledge on innate immune cells is useful to predict and solve human ailments with underlying immunopathologies. Evidence of the interaction between the innate and adaptive immune cells can be borne out of in vitro, in vivo and ex vivo experiments using preclinical models as well as human primary immune cells, be it in natural as well as in vaccine related immune responses against infectious diseases or cancer. Observations derived from human data in ‘steady state’ as well as from patients undergoing therapy and from humanized immune system mice can greatly improve our knowledge. Recent advancements in investigations focused on human immunopathologies as well as in instances where the immune system impedes delivery and action of biological therapeutics, provide opportunities to validate and extend the relevance of the role of innate immune cells in mechanistically controlling adaptive immune responses. Further, it is also important to understand the role of innate immune cells in the development of autoimmune and autoinflammatory responses as well as in cases of immunogenicity against protein, gene and cell therapeutics.
This Research Topic welcomes the submission of manuscripts focusing on, but not limited to, the following sub-topics:
• Human innate immune cells in different tissues: phenotype, development and function in physiopathology
• Activation and regulation of T cells and B cells by innate immune cells (MNPs, PMNs, NK cells and ILCs) resulting in human immunopathologies
• Tolerance inducing pathways in human antigen presenting cells and modulation of adaptive immune responses
• Murine models with Humanized Immune system – tools to study innate adaptive immune cross-talks in humans
• Immunogenicity of protein, gene and cell therapeutics: role of innate immune cells in human and non-human in vivo and in vitro models
