In recent years, increasing attention has been paid to the study of edible mushrooms that demonstrate medicinal functions. Mushrooms, such as Ganoderma sichuanense, Lentinula edodes, Ganoderma applanatum, and Irpex lacteus that exhibit immunoregulatory properties have been applied in clinical settings. Although mushrooms contain various active compounds, most studies have only focused on their crude polysaccharides. For example, polysaccharides from Cordyceps militaris have been found to stimulate immune responses by activating macrophages through MAPK and NF-?B signaling pathways. Crude polysaccharides from the milky mushroom have been reported to regulate the innate immunity of macrophages by triggering the MyD88-dependent TLR4/NF-?B pathway. Most such polysaccharides have been studied directly from crude mushroom extracts without a clear structural analysis. Furthermore, although active compounds from mushrooms play a role in certain well-known signaling pathways involved in immune regulation, their mechanism of action and target cells/molecules remain unclear.
The goal of this Research Topic is to identify immunomodulatory compounds purified from mushrooms and to explore their immune regulatory mechanisms, including their mechanisms of action and targets such as immune cells/molecules. Submissions on this topic will not only introduce new active compounds from mushrooms but also reveal novel immune regulatory mechanisms. Submitted manuscripts should adhere to the following requirements and scope:
1. The active compounds studied must be purified from mushrooms and subjected to explicit structural analysis. These compounds include, but are not limited to, polysaccharides, alkaloids, flavonoids, and various monomers.
2. The purified and structurally appraised compounds from mushrooms must demonstrate effects on immune regulation. Data obtained from in vitro experiments must be confirmed in animal models or preferably in clinical trials.
3. The study must clarify the mechanisms of action of the active compounds in the following areas, with clear delineation of their targets, such as cells and cytokines associated with immune functions:
(1) Autoregulation: the interaction of immune cells and immune molecules within the immune system;
(2) Global regulation: the interaction between the neuroendocrine and immune systems.
In recent years, increasing attention has been paid to the study of edible mushrooms that demonstrate medicinal functions. Mushrooms, such as Ganoderma sichuanense, Lentinula edodes, Ganoderma applanatum, and Irpex lacteus that exhibit immunoregulatory properties have been applied in clinical settings. Although mushrooms contain various active compounds, most studies have only focused on their crude polysaccharides. For example, polysaccharides from Cordyceps militaris have been found to stimulate immune responses by activating macrophages through MAPK and NF-?B signaling pathways. Crude polysaccharides from the milky mushroom have been reported to regulate the innate immunity of macrophages by triggering the MyD88-dependent TLR4/NF-?B pathway. Most such polysaccharides have been studied directly from crude mushroom extracts without a clear structural analysis. Furthermore, although active compounds from mushrooms play a role in certain well-known signaling pathways involved in immune regulation, their mechanism of action and target cells/molecules remain unclear.
The goal of this Research Topic is to identify immunomodulatory compounds purified from mushrooms and to explore their immune regulatory mechanisms, including their mechanisms of action and targets such as immune cells/molecules. Submissions on this topic will not only introduce new active compounds from mushrooms but also reveal novel immune regulatory mechanisms. Submitted manuscripts should adhere to the following requirements and scope:
1. The active compounds studied must be purified from mushrooms and subjected to explicit structural analysis. These compounds include, but are not limited to, polysaccharides, alkaloids, flavonoids, and various monomers.
2. The purified and structurally appraised compounds from mushrooms must demonstrate effects on immune regulation. Data obtained from in vitro experiments must be confirmed in animal models or preferably in clinical trials.
3. The study must clarify the mechanisms of action of the active compounds in the following areas, with clear delineation of their targets, such as cells and cytokines associated with immune functions:
(1) Autoregulation: the interaction of immune cells and immune molecules within the immune system;
(2) Global regulation: the interaction between the neuroendocrine and immune systems.
