About this Research Topic
While the mechanistic processes mediating beta-cell death in both Type 1 and Type 2 diabetes are quite well described, we have much less understanding of the hierarchy, cross-talk, and interplay of the various cell death mechanisms. Moreover, the role of other islet cell types in beta-cell dysfunction and death is not fully understood. Better knowledge of the ‘big picture’ of beta-cell senescence and death will help to advance therapeutic interventions, for example, the development of new drugs as well as other promising strategies, including islet transplantation.
We welcome different kinds of articles, including original research articles, reviews, mini-reviews, and opinion/perspectives, which cover, but not limited to, the following themes:
- how different pathways interconnect, communicate and influence each other in pancreatic islets in Type 1 and Type 2 diabetes;
- new information on the complex pancreatic setting, elucidating pathways hierarchy, interplays, and cross-talks;
- the molecular basis of different therapeutic strategies, in particular the effect of different drugs on the molecular pathways and the mechanisms of islet adaptation during transplantation.
Keywords: Pancreatic islet, diabetes, molecular mechanisms, beta cell death, crosstalk
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