Transplantation has been a breakthrough therapy for end-stage organ failure. However, transplant-related injury compromises the graft function and recipient survival. To date, protecting donor organs before transplantation and modulating the allogeneic immune response after grafting represent two major challenges in the transplantation field. Regarding donor organ protection, accumulating advances have emerged to improve short- and long-term survival, especially in kidney/pancreas-kidney transplantation which accounts for a large proportion of clinical requirements. The most studied topics are molecular and cellular mechanisms and approaches, including ischemia/reperfusion injury, organ preservation methods, specific and aspecific inflammation/fibrosis, and aging. Further on, donor organ damage is closely related to innate immunity and may trigger adaptive immunity. After transplantation, antigen-presenting cells (APCs) and T/B cells play pivotal roles in regulating immunological injuries including cellular and humoral mediated rejection throughout the whole transplantation process. Therefore, investigation focusing on rejection, tolerance, and regulation always maintains active and attractive. Various factors, such as cytokines, soluble mediators, and membrane/cytosol/nuclear molecules orchestrated to explore the mechanism and approaches against the transplant-related injury.
Based on the background above, our goal of this Research Topic is to provide a forum to showcase the research advances of novel molecular/cellular mechanisms and approaches against kidney/pancreas-kidney transplant-related injury. We call for papers that reveal the mechanisms in protecting kidney/pancreas and modulating APCs and T/B cells in transplantation as well as studies showing new pharmacological/molecular/cellular interventions, gene therapy, and biomarker that improve the graft function and promote graft survival.
We welcome submissions of Original Research (basic and clinical research), Case reports, and Review articles focusing on, but not limited to, the following aspects:
1. Novel molecular and cellular mechanisms and approaches for alleviating kidney/pancreas donor injury
2. Novel molecular and cellular mechanisms of the interaction between innate immunity and adaptive immunity in kidney/pancreas-kidney transplantation
3. Novel mechanism and approaches focusing on APCs and T/B cells to modulate rejection, tolerance, and regulation after kidney/pancreas-kidney transplantation
4. Development of diagnostic and prognostic biomarkers in kidney/pancreas-kidney transplantation
Transplantation has been a breakthrough therapy for end-stage organ failure. However, transplant-related injury compromises the graft function and recipient survival. To date, protecting donor organs before transplantation and modulating the allogeneic immune response after grafting represent two major challenges in the transplantation field. Regarding donor organ protection, accumulating advances have emerged to improve short- and long-term survival, especially in kidney/pancreas-kidney transplantation which accounts for a large proportion of clinical requirements. The most studied topics are molecular and cellular mechanisms and approaches, including ischemia/reperfusion injury, organ preservation methods, specific and aspecific inflammation/fibrosis, and aging. Further on, donor organ damage is closely related to innate immunity and may trigger adaptive immunity. After transplantation, antigen-presenting cells (APCs) and T/B cells play pivotal roles in regulating immunological injuries including cellular and humoral mediated rejection throughout the whole transplantation process. Therefore, investigation focusing on rejection, tolerance, and regulation always maintains active and attractive. Various factors, such as cytokines, soluble mediators, and membrane/cytosol/nuclear molecules orchestrated to explore the mechanism and approaches against the transplant-related injury.
Based on the background above, our goal of this Research Topic is to provide a forum to showcase the research advances of novel molecular/cellular mechanisms and approaches against kidney/pancreas-kidney transplant-related injury. We call for papers that reveal the mechanisms in protecting kidney/pancreas and modulating APCs and T/B cells in transplantation as well as studies showing new pharmacological/molecular/cellular interventions, gene therapy, and biomarker that improve the graft function and promote graft survival.
We welcome submissions of Original Research (basic and clinical research), Case reports, and Review articles focusing on, but not limited to, the following aspects:
1. Novel molecular and cellular mechanisms and approaches for alleviating kidney/pancreas donor injury
2. Novel molecular and cellular mechanisms of the interaction between innate immunity and adaptive immunity in kidney/pancreas-kidney transplantation
3. Novel mechanism and approaches focusing on APCs and T/B cells to modulate rejection, tolerance, and regulation after kidney/pancreas-kidney transplantation
4. Development of diagnostic and prognostic biomarkers in kidney/pancreas-kidney transplantation