In the mid-1960s, Peter Wolf revolutionized the understanding of intercellular communication by introducing for the first time tiny entities, extracellular vesicles (EVs), as cell free-signalling conveyers. EV are submicron-sized membranous biological vesicles that are involved in the exchange of a wide range of functional biomolecules (lipid, protein, mRNA and miRNA) between normal and diseased cells. Several studies now appreciate that the cargo of an EV is a reflection of the pathophysiological condition of the cell of origin and is tightly linked to the stage of disease.
In the era of precision medicine, substantial research has recently been devoted to discovering the translational potential of EVs. EVs may have a role as a reliable liquid biopsy in the diagnosis and monitoring of several life-affecting diseases, including chronic inflammatory diseases. So far, the role of EV in inflammatory responses and hence their role in the development of inflammation-associated diseases remains largely unknown. In addition, there is a long-standing gap between initial EV-based diagnostic platforms and clinical translation. Therefore, the goal of this section is to cover the recent findings about the role of EVs in inflammatory responses as well as inflammation-associated disease. Finally, the ultimate goal of this section is to provide a comprehensive overview of the clinically relevant studies with a focus on inflammation-associated diseases to fill the gap between EV research and their translational application in precision medicine.
In this special issue, we invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Extracellular vesicles in inflammatory responses and inflammation-associated diseases”. The scope of this issue will include clinically relevant areas of investigation which apply to the following areas:
• The multicomponent nature of EVs in inflammatory responses: content and function
• The role of EVs in the pathophysiology of inflammatory responses and disease
• EV molecular signatures in inflammation-associated diseases
• Clinically relevant EV studies with particular focus on inflammation-associated disease
• Use of EV in precision medicine in relation to inflammatory diseases.
In the mid-1960s, Peter Wolf revolutionized the understanding of intercellular communication by introducing for the first time tiny entities, extracellular vesicles (EVs), as cell free-signalling conveyers. EV are submicron-sized membranous biological vesicles that are involved in the exchange of a wide range of functional biomolecules (lipid, protein, mRNA and miRNA) between normal and diseased cells. Several studies now appreciate that the cargo of an EV is a reflection of the pathophysiological condition of the cell of origin and is tightly linked to the stage of disease.
In the era of precision medicine, substantial research has recently been devoted to discovering the translational potential of EVs. EVs may have a role as a reliable liquid biopsy in the diagnosis and monitoring of several life-affecting diseases, including chronic inflammatory diseases. So far, the role of EV in inflammatory responses and hence their role in the development of inflammation-associated diseases remains largely unknown. In addition, there is a long-standing gap between initial EV-based diagnostic platforms and clinical translation. Therefore, the goal of this section is to cover the recent findings about the role of EVs in inflammatory responses as well as inflammation-associated disease. Finally, the ultimate goal of this section is to provide a comprehensive overview of the clinically relevant studies with a focus on inflammation-associated diseases to fill the gap between EV research and their translational application in precision medicine.
In this special issue, we invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the theme of “Extracellular vesicles in inflammatory responses and inflammation-associated diseases”. The scope of this issue will include clinically relevant areas of investigation which apply to the following areas:
• The multicomponent nature of EVs in inflammatory responses: content and function
• The role of EVs in the pathophysiology of inflammatory responses and disease
• EV molecular signatures in inflammation-associated diseases
• Clinically relevant EV studies with particular focus on inflammation-associated disease
• Use of EV in precision medicine in relation to inflammatory diseases.
