Brain metastasis is the most common malignancy of central nervous system tumors. The majority of brain metastases, approximately between 20-55%, have been found to develop from non-small cell lung cancer (NSCLC) with a poor prognosis for patients. The main form of brain metastasis treatment has evolved over time including localized therapies such as surgical treatment dependent on the stage and location of the metastatic disease and has been found to improve prognosis in addition to post-post-operative radiotherapy to avoid local recurrence. Other forms of radiotherapies include stereotactic radiosurgery (SRS), three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiation therapy (IMRT), or combinations of the above treatments, together with systemic therapies including chemotherapy, immunotherapy and molecular targeted therapies including tyrosine kinase inhibitors. However, these combinations have demonstrated poor prognosis and survival rate which highlights a requirement for further studies to identify alternative strategies for treatment and therapies.
Stereotactic radiotherapy (SRT) is one of the most important developments in the treatment of brain metastasis. However, there are other forms of radiation therapies including Fractionated Stereotactic Radiotherapy (FSRT) and Single-Session Radiosurgery (SRS) which need to be further explored as potential alternative strategies of treatment. Studies have suggested that FSRT may increase the therapeutic ratio compared to SRS in patients due to high spatial precision in addition to the ability to identify radiobiological differences between brain metastases and surrounding normal non-cancerous brain tissue. However, further studies are required to establish how FSRT can be utilised in brain metastasis treatment.
The goal of this Research Topic is to generate an active discussion of the impact and influence of radiation therapies on brain metastasis, the current forms of treatment and alternative lines of radiation therapies that can be explored. We welcome Original Research Articles, Review Articles, Systematic Reviews and Case Reports. Topics of interest include:
-Whole body radiation therapy
-Stereotactic radiotherapy
-Fractionated stereotactic radiotherapy
-Single-session radiosurgery
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Brain metastasis is the most common malignancy of central nervous system tumors. The majority of brain metastases, approximately between 20-55%, have been found to develop from non-small cell lung cancer (NSCLC) with a poor prognosis for patients. The main form of brain metastasis treatment has evolved over time including localized therapies such as surgical treatment dependent on the stage and location of the metastatic disease and has been found to improve prognosis in addition to post-post-operative radiotherapy to avoid local recurrence. Other forms of radiotherapies include stereotactic radiosurgery (SRS), three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiation therapy (IMRT), or combinations of the above treatments, together with systemic therapies including chemotherapy, immunotherapy and molecular targeted therapies including tyrosine kinase inhibitors. However, these combinations have demonstrated poor prognosis and survival rate which highlights a requirement for further studies to identify alternative strategies for treatment and therapies.
Stereotactic radiotherapy (SRT) is one of the most important developments in the treatment of brain metastasis. However, there are other forms of radiation therapies including Fractionated Stereotactic Radiotherapy (FSRT) and Single-Session Radiosurgery (SRS) which need to be further explored as potential alternative strategies of treatment. Studies have suggested that FSRT may increase the therapeutic ratio compared to SRS in patients due to high spatial precision in addition to the ability to identify radiobiological differences between brain metastases and surrounding normal non-cancerous brain tissue. However, further studies are required to establish how FSRT can be utilised in brain metastasis treatment.
The goal of this Research Topic is to generate an active discussion of the impact and influence of radiation therapies on brain metastasis, the current forms of treatment and alternative lines of radiation therapies that can be explored. We welcome Original Research Articles, Review Articles, Systematic Reviews and Case Reports. Topics of interest include:
-Whole body radiation therapy
-Stereotactic radiotherapy
-Fractionated stereotactic radiotherapy
-Single-session radiosurgery
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
